Selective cytotoxicity of azatyrosinamides against ras-transformed NIH 3T3 cells

H. P. Wang*, T. L. Hwang, On Lee, Y. J. Tseng, C. Y. Shu, S. J. Lee

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

5 Scopus citations


This study aims to develop novel azatyrosinamide compounds structurally modified from ras-specific antioncogenic azatyrosine. Analogues 4-15 were prepared and their inhibition on the growth of wild-type and ras-transformed NIH 3T3 cell lines was compared. Compound 12 was found to be the most active with IC50 16.5 ± 2.2 μM which is 458-fold more potent than that of azatyrosine. The selective toxicity, defined as IC 50 wild-type/IC50 ras-transformed for this compound was 138.5.

Original languageEnglish
Pages (from-to)4272-4274
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Issue number19
StatePublished - 01 10 2005


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