Selective Inhibition of Collagen-Induced Platelet Aggregation by a Cyclic Peptide from Drymaria diandra

Pei Wen Hsieh; Fang Rong Chang; Chin Chuang Wu; Kuen Yuh Wu; Chien Ming Li; Wei Ya Wang; Ling Chia Gu; Yang Chang Wu

doi:10.1002/hlca.200490017

Selective Inhibition of Collagen-Induced Platelet Aggregation by a Cyclic Peptide from Drymaria diandra

Pei Wen Hsieh
, Fang Rong Chang
, Chin Chuang Wu
, Kuen Yuh Wu
, Chien Ming Li
, Wei Ya Wang
, Ling Chia Gu
, Yang Chang Wu^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

17 Scopus citations

Abstract

Four cyclic peptides, diandrine A - D (1 - 4), were isolated from the MeOH extract of Formosan Drymaria diandra. Their structures were elucidated by chemical and spectroscopic analyses as cyclo(-Gly¹-Pro ²-Trp³-Pro⁴-Tyr⁵-Phe⁶-), cyclo(-Gly¹Pro²-Leu³-Pro⁴-Leu ⁵-Trp⁶-Ser⁷-Ser⁸-), cyclo(Gly ¹Gly²-Pro³-Tyr⁴-Trp ⁵-Pro⁶-), and cyclo(Gly¹-Gly ²-Pro³-Tyr⁴-Trp⁵-Pro⁶-), respectively. Compounds 3 and 4 were stable conformational isomers. Cyclopeptide 1 showed a selective inhibitory effect on collagen-induced platelet aggregation with an IC₅₀ value of 44.2 μM.

Original language	English
Pages (from-to)	57-66
Number of pages	10
Journal	Helvetica Chimica Acta
Volume	87
Issue number	1
DOIs	https://doi.org/10.1002/hlca.200490017
State	Published - 2004
Externally published	Yes

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title = "Selective Inhibition of Collagen-Induced Platelet Aggregation by a Cyclic Peptide from Drymaria diandra",

abstract = "Four cyclic peptides, diandrine A - D (1 - 4), were isolated from the MeOH extract of Formosan Drymaria diandra. Their structures were elucidated by chemical and spectroscopic analyses as cyclo(-Gly1-Pro 2-Trp3-Pro4-Tyr5-Phe6-), cyclo(-Gly1Pro2-Leu3-Pro4-Leu 5-Trp6-Ser7-Ser8-), cyclo(Gly 1Gly2-Pro3-Tyr4-Trp 5-Pro6-), and cyclo(Gly1-Gly 2-Pro3-Tyr4-Trp5-Pro6-), respectively. Compounds 3 and 4 were stable conformational isomers. Cyclopeptide 1 showed a selective inhibitory effect on collagen-induced platelet aggregation with an IC50 value of 44.2 μM.",

author = "Hsieh, \{Pei Wen\} and Chang, \{Fang Rong\} and Wu, \{Chin Chuang\} and Wu, \{Kuen Yuh\} and Li, \{Chien Ming\} and Wang, \{Wei Ya\} and Gu, \{Ling Chia\} and Wu, \{Yang Chang\}",

year = "2004",

doi = "10.1002/hlca.200490017",

language = "英语",

volume = "87",

pages = "57--66",

journal = "Helvetica Chimica Acta",

issn = "0018-019X",

publisher = "Wiley-Blackwell",

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TY - JOUR

T1 - Selective Inhibition of Collagen-Induced Platelet Aggregation by a Cyclic Peptide from Drymaria diandra

AU - Hsieh, Pei Wen

AU - Chang, Fang Rong

AU - Wu, Chin Chuang

AU - Wu, Kuen Yuh

AU - Li, Chien Ming

AU - Wang, Wei Ya

AU - Gu, Ling Chia

AU - Wu, Yang Chang

PY - 2004

Y1 - 2004

N2 - Four cyclic peptides, diandrine A - D (1 - 4), were isolated from the MeOH extract of Formosan Drymaria diandra. Their structures were elucidated by chemical and spectroscopic analyses as cyclo(-Gly1-Pro 2-Trp3-Pro4-Tyr5-Phe6-), cyclo(-Gly1Pro2-Leu3-Pro4-Leu 5-Trp6-Ser7-Ser8-), cyclo(Gly 1Gly2-Pro3-Tyr4-Trp 5-Pro6-), and cyclo(Gly1-Gly 2-Pro3-Tyr4-Trp5-Pro6-), respectively. Compounds 3 and 4 were stable conformational isomers. Cyclopeptide 1 showed a selective inhibitory effect on collagen-induced platelet aggregation with an IC50 value of 44.2 μM.

AB - Four cyclic peptides, diandrine A - D (1 - 4), were isolated from the MeOH extract of Formosan Drymaria diandra. Their structures were elucidated by chemical and spectroscopic analyses as cyclo(-Gly1-Pro 2-Trp3-Pro4-Tyr5-Phe6-), cyclo(-Gly1Pro2-Leu3-Pro4-Leu 5-Trp6-Ser7-Ser8-), cyclo(Gly 1Gly2-Pro3-Tyr4-Trp 5-Pro6-), and cyclo(Gly1-Gly 2-Pro3-Tyr4-Trp5-Pro6-), respectively. Compounds 3 and 4 were stable conformational isomers. Cyclopeptide 1 showed a selective inhibitory effect on collagen-induced platelet aggregation with an IC50 value of 44.2 μM.

UR - https://www.scopus.com/pages/publications/1342323919

U2 - 10.1002/hlca.200490017

DO - 10.1002/hlca.200490017

M3 - 文章

AN - SCOPUS:1342323919

SN - 0018-019X

VL - 87

SP - 57

EP - 66

JO - Helvetica Chimica Acta

JF - Helvetica Chimica Acta

IS - 1

ER -

Selective Inhibition of Collagen-Induced Platelet Aggregation by a Cyclic Peptide from Drymaria diandra

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