Abstract
Aim: Whether the obesity prevention by chemicals or surgeries in already obese patients is the better choice remains controversial. We aimed to compare the effect of orally silibinin-loaded nanocarriers and Roux-en-Y gastric bypass surgery on hepatic fibrosis in high-fat feeding-induced obese rats. Methodology: The developed nanocarriers included self-emulsifying drug delivery system (SNEDDS) and nanostructured lipid carriers (NLC). Results: A significant decrease in collagen production and lipid droplet formation was observed upon nanosystem and bariatric surgery than the rats treated with silibinin control suspension. Stage 3 fibrosis was present in 33% of the obese rats. This percentage could be minimized to 0% by SNEDDS and NLC. Following oral administration, SNEDDS and NLC resulted in 3.5- and 2.9-fold increase, respectively, in bioavailability compared with the reference suspension. Conclusion: Nanomedicine prevention provided a comparable efficiency to ameliorate liver steatosis as Roux-en-Y gastric bypass due to the improvement of silibinin dissolution and gastrointestinal permeation.
| Original language | English |
|---|---|
| Pages (from-to) | 1551-1566 |
| Number of pages | 16 |
| Journal | Nanomedicine |
| Volume | 13 |
| Issue number | 13 |
| DOIs | |
| State | Published - 07 2018 |
Bibliographical note
Publisher Copyright:© 2018 Future Medicine Ltd.
Keywords
- Liver fibrosis
- Roux-en-Y gastric bypass
- nanostructured lipid carriers
- obesity
- self-emulsifying drug delivery system
- silibinin
