Abstract
It is imperative to develop tools to characterize cells with the diseased and normal mitochondria to monitor the healthiness of cells and take preventive measures for potential mitochondrial disease development. Here, we adopt insulator dielectrophoresis (i-DEP), by utilizing the intrinsic dielectric response of a cell to an external AC electric field to differentiate cells, containing partially diseased and normal mitochondria. Taking advantage of dielectrophoresis, DEP, principle, we developed a quick diagnostic method to detect mitochondrial disease in living cells, which is not readily achievable by conventional cell cytometry.
Original language | English |
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Title of host publication | 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 |
Publisher | Chemical and Biological Microsystems Society |
Pages | 1372-1373 |
Number of pages | 2 |
ISBN (Electronic) | 9781733419000 |
State | Published - 2019 |
Externally published | Yes |
Event | 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 - Basel, Switzerland Duration: 27 10 2019 → 31 10 2019 |
Publication series
Name | 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 |
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Conference
Conference | 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 |
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Country/Territory | Switzerland |
City | Basel |
Period | 27/10/19 → 31/10/19 |
Bibliographical note
Publisher Copyright:© 2019 CBMS-0001.
Keywords
- Chip
- Diagnosis
- Dielectrophoresis (DEP)
- Microfluidic
- Mitochondria