Sequential changes of serum aminotransferase levels in patients with severe acute respiratory syndrome

Keng Liang Wu; Sheng Nan Lu; Chi Sin Changchien; King Wah Chiu; Chung Huang Kuo; Seng Kee Chuah; Jien Wei Liu; Meng Chih Lin; Hock Liew Eng; Shun Sheng Chen; Chuan Mo Lee; Chao Long Chen

doi:10.4269/ajtmh.2004.71.125

Sequential changes of serum aminotransferase levels in patients with severe acute respiratory syndrome

Keng Liang Wu, Sheng Nan Lu, Chi Sin Changchien, King Wah Chiu, Chung Huang Kuo, Seng Kee Chuah, Jien Wei Liu, Meng Chih Lin, Hock Liew Eng, Shun Sheng Chen, Chuan Mo Lee^*, Chao Long Chen

^*Corresponding author for this work

Chang Gung Memorial Hospital

Research output: Contribution to journal › Journal Article › peer-review

20 Scopus citations

Abstract

Severe acute respiratory syndrome (SARS) is a newly emerging infectious disease. To describe the hepatic injury caused by this disease, we report the sequential changes of serum transaminase in probable SARS patients during a hospital outbreak in southern Taiwan. From April to June, 2003, 52 probable SARS patients were hospitalized. Serial serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were retrospectively analyzed and hepatitis B surface antigen (HBsAg) was also evaluated to correlate with the progression of this disease. Fifty-three percent of the patients had abnormal liver function during hospitalization. More than 70% of abnormal transaminase levels were mildly elevated. Most elevated levels were noted during the second week after onset of fever. Neither transaminase elevation nor HBsAg was related to the prognosis of SARS, and only advanced age was an independent predictor of poor outcome. Our study suggested that coronavirus causing SARS might induce liver damage.

Original language	English
Pages (from-to)	125-128
Number of pages	4
Journal	American Journal of Tropical Medicine and Hygiene
Volume	71
Issue number	2
DOIs	https://doi.org/10.4269/ajtmh.2004.71.125
State	Published - 08 2004
Externally published	Yes

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Wu, K. L., Lu, S. N., Changchien, C. S., Chiu, K. W., Kuo, C. H., Chuah, S. K., Liu, J. W., Lin, M. C., Eng, H. L., Chen, S. S., Lee, C. M., & Chen, C. L. (2004). Sequential changes of serum aminotransferase levels in patients with severe acute respiratory syndrome. American Journal of Tropical Medicine and Hygiene, 71(2), 125-128. https://doi.org/10.4269/ajtmh.2004.71.125

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title = "Sequential changes of serum aminotransferase levels in patients with severe acute respiratory syndrome",

abstract = "Severe acute respiratory syndrome (SARS) is a newly emerging infectious disease. To describe the hepatic injury caused by this disease, we report the sequential changes of serum transaminase in probable SARS patients during a hospital outbreak in southern Taiwan. From April to June, 2003, 52 probable SARS patients were hospitalized. Serial serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were retrospectively analyzed and hepatitis B surface antigen (HBsAg) was also evaluated to correlate with the progression of this disease. Fifty-three percent of the patients had abnormal liver function during hospitalization. More than 70% of abnormal transaminase levels were mildly elevated. Most elevated levels were noted during the second week after onset of fever. Neither transaminase elevation nor HBsAg was related to the prognosis of SARS, and only advanced age was an independent predictor of poor outcome. Our study suggested that coronavirus causing SARS might induce liver damage.",

author = "Wu, {Keng Liang} and Lu, {Sheng Nan} and Changchien, {Chi Sin} and Chiu, {King Wah} and Kuo, {Chung Huang} and Chuah, {Seng Kee} and Liu, {Jien Wei} and Lin, {Meng Chih} and Eng, {Hock Liew} and Chen, {Shun Sheng} and Lee, {Chuan Mo} and Chen, {Chao Long}",

year = "2004",

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doi = "10.4269/ajtmh.2004.71.125",

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volume = "71",

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T1 - Sequential changes of serum aminotransferase levels in patients with severe acute respiratory syndrome

AU - Wu, Keng Liang

AU - Lu, Sheng Nan

AU - Changchien, Chi Sin

AU - Chiu, King Wah

AU - Kuo, Chung Huang

AU - Chuah, Seng Kee

AU - Liu, Jien Wei

AU - Lin, Meng Chih

AU - Eng, Hock Liew

AU - Chen, Shun Sheng

AU - Lee, Chuan Mo

AU - Chen, Chao Long

PY - 2004/8

Y1 - 2004/8

N2 - Severe acute respiratory syndrome (SARS) is a newly emerging infectious disease. To describe the hepatic injury caused by this disease, we report the sequential changes of serum transaminase in probable SARS patients during a hospital outbreak in southern Taiwan. From April to June, 2003, 52 probable SARS patients were hospitalized. Serial serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were retrospectively analyzed and hepatitis B surface antigen (HBsAg) was also evaluated to correlate with the progression of this disease. Fifty-three percent of the patients had abnormal liver function during hospitalization. More than 70% of abnormal transaminase levels were mildly elevated. Most elevated levels were noted during the second week after onset of fever. Neither transaminase elevation nor HBsAg was related to the prognosis of SARS, and only advanced age was an independent predictor of poor outcome. Our study suggested that coronavirus causing SARS might induce liver damage.

AB - Severe acute respiratory syndrome (SARS) is a newly emerging infectious disease. To describe the hepatic injury caused by this disease, we report the sequential changes of serum transaminase in probable SARS patients during a hospital outbreak in southern Taiwan. From April to June, 2003, 52 probable SARS patients were hospitalized. Serial serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were retrospectively analyzed and hepatitis B surface antigen (HBsAg) was also evaluated to correlate with the progression of this disease. Fifty-three percent of the patients had abnormal liver function during hospitalization. More than 70% of abnormal transaminase levels were mildly elevated. Most elevated levels were noted during the second week after onset of fever. Neither transaminase elevation nor HBsAg was related to the prognosis of SARS, and only advanced age was an independent predictor of poor outcome. Our study suggested that coronavirus causing SARS might induce liver damage.

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U2 - 10.4269/ajtmh.2004.71.125

DO - 10.4269/ajtmh.2004.71.125

M3 - 文章

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AN - SCOPUS:4243159777

SN - 0002-9637

VL - 71

SP - 125

EP - 128

JO - American Journal of Tropical Medicine and Hygiene

JF - American Journal of Tropical Medicine and Hygiene

IS - 2

ER -

Sequential changes of serum aminotransferase levels in patients with severe acute respiratory syndrome

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