Seroprevalence of SARS coronavirus among residents near a hospital with a nosocomial outbreak

Ming Han Tsai; Tzou Yien Lin; Cheng Hsun Chiu; Pen Yi Lin; Yhu Chering Huang; Kuo Chien Tsao; Chung Guei Huang; Kuang Hung Hsu; Meng Chih Lin; Kao Pin Hwang; Kuender D. Yang; Tzou Yien Lin

doi:10.1016/S0929-6646(08)60205-3

Seroprevalence of SARS coronavirus among residents near a hospital with a nosocomial outbreak

Ming Han Tsai, Tzou Yien Lin^*, Cheng Hsun Chiu, Pen Yi Lin, Yhu Chering Huang, Kuo Chien Tsao, Chung Guei Huang, Kuang Hung Hsu, Meng Chih Lin, Kao Pin Hwang, Kuender D. Yang, Tzou Yien Lin^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

2 Scopus citations

Abstract

Background/Purpose: An epidemic of severe acute respiratory syndrome (SARS) occurred in Taiwan from April to July 2003. A nosocomial outbreak of SARS occurred at Kaohsiung Chang Gung Memorial Hospital (CGMH) in May 2003. The purpose of our study was to survey the prevalence of the SARS coronavirus (CoV) in a community adjacent to Kaohsiung CGMH and collect demographic data, including basic information about health status, household, and possible risk factors for SARS-CoV infection. Methods: We randomly recruited 1030 persons living in three precincts adjacent to Kaohsiung CGMH. For all subjects, we collected demographic data and measured the seroprevalence of the SARS-CoV with an enzyme-linked immunosorbent assay (ELISA) and an immunofluorescence assay (IFA). Results: The ELISA was seropositive for 124 of 1030 participants (12%). The more sensitive and specific IFA confirmed SARS in only two cases (0. 19%). Both confirmed cases were under 19 years of age and had no known SARS-related risk factors. Conclusion: There was low post-epidemic seroprevalence of SARS-CoV in a community adjacent to a hospital which had a nosocomial SARS outbreak. The SARS outbreak in Taiwan was primarily limited to hospital settings.

Original language	English
Pages (from-to)	885-891
Number of pages	7
Journal	Journal of the Formosan Medical Association
Volume	107
Issue number	11
DOIs	https://doi.org/10.1016/S0929-6646(08)60205-3
State	Published - 11 2008

Keywords

Community survey
Nosocomial infections
SARS-CoV
Seroprevalence

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10.1016/S0929-6646(08)60205-3

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title = "Seroprevalence of SARS coronavirus among residents near a hospital with a nosocomial outbreak",

abstract = "Background/Purpose: An epidemic of severe acute respiratory syndrome (SARS) occurred in Taiwan from April to July 2003. A nosocomial outbreak of SARS occurred at Kaohsiung Chang Gung Memorial Hospital (CGMH) in May 2003. The purpose of our study was to survey the prevalence of the SARS coronavirus (CoV) in a community adjacent to Kaohsiung CGMH and collect demographic data, including basic information about health status, household, and possible risk factors for SARS-CoV infection. Methods: We randomly recruited 1030 persons living in three precincts adjacent to Kaohsiung CGMH. For all subjects, we collected demographic data and measured the seroprevalence of the SARS-CoV with an enzyme-linked immunosorbent assay (ELISA) and an immunofluorescence assay (IFA). Results: The ELISA was seropositive for 124 of 1030 participants (12%). The more sensitive and specific IFA confirmed SARS in only two cases (0. 19%). Both confirmed cases were under 19 years of age and had no known SARS-related risk factors. Conclusion: There was low post-epidemic seroprevalence of SARS-CoV in a community adjacent to a hospital which had a nosocomial SARS outbreak. The SARS outbreak in Taiwan was primarily limited to hospital settings.",

keywords = "Community survey, Nosocomial infections, SARS-CoV, Seroprevalence",

author = "Tsai, {Ming Han} and Lin, {Tzou Yien} and Chiu, {Cheng Hsun} and Lin, {Pen Yi} and Huang, {Yhu Chering} and Tsao, {Kuo Chien} and Huang, {Chung Guei} and Hsu, {Kuang Hung} and Lin, {Meng Chih} and Hwang, {Kao Pin} and Yang, {Kuender D.} and Lin, {Tzou Yien}",

year = "2008",

month = nov,

doi = "10.1016/S0929-6646(08)60205-3",

language = "英语",

volume = "107",

pages = "885--891",

journal = "Journal of the Formosan Medical Association",

issn = "0929-6646",

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T1 - Seroprevalence of SARS coronavirus among residents near a hospital with a nosocomial outbreak

AU - Tsai, Ming Han

AU - Lin, Tzou Yien

AU - Chiu, Cheng Hsun

AU - Lin, Pen Yi

AU - Huang, Yhu Chering

AU - Tsao, Kuo Chien

AU - Huang, Chung Guei

AU - Hsu, Kuang Hung

AU - Lin, Meng Chih

AU - Hwang, Kao Pin

AU - Yang, Kuender D.

AU - Lin, Tzou Yien

PY - 2008/11

Y1 - 2008/11

N2 - Background/Purpose: An epidemic of severe acute respiratory syndrome (SARS) occurred in Taiwan from April to July 2003. A nosocomial outbreak of SARS occurred at Kaohsiung Chang Gung Memorial Hospital (CGMH) in May 2003. The purpose of our study was to survey the prevalence of the SARS coronavirus (CoV) in a community adjacent to Kaohsiung CGMH and collect demographic data, including basic information about health status, household, and possible risk factors for SARS-CoV infection. Methods: We randomly recruited 1030 persons living in three precincts adjacent to Kaohsiung CGMH. For all subjects, we collected demographic data and measured the seroprevalence of the SARS-CoV with an enzyme-linked immunosorbent assay (ELISA) and an immunofluorescence assay (IFA). Results: The ELISA was seropositive for 124 of 1030 participants (12%). The more sensitive and specific IFA confirmed SARS in only two cases (0. 19%). Both confirmed cases were under 19 years of age and had no known SARS-related risk factors. Conclusion: There was low post-epidemic seroprevalence of SARS-CoV in a community adjacent to a hospital which had a nosocomial SARS outbreak. The SARS outbreak in Taiwan was primarily limited to hospital settings.

AB - Background/Purpose: An epidemic of severe acute respiratory syndrome (SARS) occurred in Taiwan from April to July 2003. A nosocomial outbreak of SARS occurred at Kaohsiung Chang Gung Memorial Hospital (CGMH) in May 2003. The purpose of our study was to survey the prevalence of the SARS coronavirus (CoV) in a community adjacent to Kaohsiung CGMH and collect demographic data, including basic information about health status, household, and possible risk factors for SARS-CoV infection. Methods: We randomly recruited 1030 persons living in three precincts adjacent to Kaohsiung CGMH. For all subjects, we collected demographic data and measured the seroprevalence of the SARS-CoV with an enzyme-linked immunosorbent assay (ELISA) and an immunofluorescence assay (IFA). Results: The ELISA was seropositive for 124 of 1030 participants (12%). The more sensitive and specific IFA confirmed SARS in only two cases (0. 19%). Both confirmed cases were under 19 years of age and had no known SARS-related risk factors. Conclusion: There was low post-epidemic seroprevalence of SARS-CoV in a community adjacent to a hospital which had a nosocomial SARS outbreak. The SARS outbreak in Taiwan was primarily limited to hospital settings.

KW - Community survey

KW - Nosocomial infections

KW - SARS-CoV

KW - Seroprevalence

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DO - 10.1016/S0929-6646(08)60205-3

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JO - Journal of the Formosan Medical Association

JF - Journal of the Formosan Medical Association

IS - 11

ER -

Seroprevalence of SARS coronavirus among residents near a hospital with a nosocomial outbreak

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