Serotype competence and penicillin resistance in Streptococcus pneumoniae

Yu Chia Hsieh, Jin Town Wang, Wen Sen Lee, Po Ren Hsueh*, Pei Lan Shao, Luan Yin Chang, Chun Yi Lu, Chin Yun Lee, Fu Yuan Huang, Li Min Huang

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

30 Scopus citations


From 2003 to 2005, we prospectively collected 118 isolates of pneumococci belonging to 7 serotypes to investigate their competence under the influence of the synthetic competence-stimulating peptides. The degree of competence of the various serotypes differed significantly. Serotype 6B had the highest competence, followed by serotypes 14, 19F, 9V, 23F, 3, and 18C. Isolates belonging to serotype 6B had greater genetic diversity than isolates belonging to serotype 3, which has high genetic clustering. Isolates belonging to serotypes 3 and 18C that were 100% sensitive to penicillin were significantly less competent than isolates belonging to serotypes 6B, 14, 19F, 9V, and 23F, which were frequently resistant to penicillin. Under the 7-valent pneumococcal conjugate vaccine program, enhanced molecular surveillance of virulent clones with higher competence to detect serotype switching will become more important.

Original languageEnglish
Pages (from-to)1709-1714
Number of pages6
JournalEmerging Infectious Diseases
Issue number11
StatePublished - 11 2006
Externally publishedYes


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