Serum complement factor I is associated with disease activity of systemic lupus erythematosus

Min Hua Tseng, Shih Hua Lin, Chao Yi Wu, Hui Ping Chien, Huang Yu Yang, Yung Chang Chen, Yu Ching Chou, Jing Long Huang*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

13 Scopus citations

Abstract

Although aberrant complement activation is involved in the pathogenesis of systemic lupus erythematosus (SLE), the role of complement regulatory proteins in disease activity of SLE remains limited. We enrolled the pediatric-onset SLE patients from our cohort study over 10 years. The clinical and laboratory data including SLEDAI disease activity score, and serum complement factor H (CFH), CFI, CD46, C5a, and C5b-9 in the active and remission phases were determined. Glomerular C5b-9 deposition as a complement activity marker was also examined. Forty patients (35 female and 5 male, aged 13.9 ± 3.8 years) met the criteria of investigation were assessed. Fever and kidney were the most common symptom and organ involved, respectively. Mean SLEDAI in the active and remission phases were 12.6 vs 1.7, respectively. All patients exhibited lower serum C3, C4, CFH and CFI and higher serum anti-dsDNA and CD46 in the active pahse. There was a significant difference in serum CFH, CFI and CD46 between active and remissive phases. Serum CFI but not CFH and CD46 level was negatively correlated with SLEDAI score in active phase. Compared to classical activity markers, serum CFI was superior to C4 and anti-dsDNA in reflecting disease activity and also significantly correlated with white blood count and hemoglobin. Glomerular C5b-9 depositions were detected in patients with nephritis during active phase but not in disease controls. Serum CFI level may not only be a promising biomarker for disease activity of SLE, but also reflects the hematological features of SLE.

Original languageEnglish
Pages (from-to)8502-8511
Number of pages10
JournalOncotarget
Volume9
Issue number9
DOIs
StatePublished - 2018

Bibliographical note

Publisher Copyright:
© Tseng et al.

Keywords

  • Biomarker
  • Complement regulatory proteins
  • Disease activity
  • Lupus nephritis
  • Systemic lupus erythematosus

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