Serum indoxyl sulfate predicts adverse cardiovascular events in patients with chronic kidney disease

Pei Chun Fan; Jason Chih Hsiang Chang; Chia Ni Lin; Cheng Chia Lee; Yi Ting Chen; Pao Hsien Chu; George Kou; Yueh An Lu; Chih Wei Yang; Yung Chang Chen

doi:10.1016/j.jfma.2019.03.005

Serum indoxyl sulfate predicts adverse cardiovascular events in patients with chronic kidney disease

Pei Chun Fan
, Jason Chih Hsiang Chang
, Chia Ni Lin
, Cheng Chia Lee
, Yi Ting Chen
, Pao Hsien Chu
, George Kou
, Yueh An Lu
, Chih Wei Yang
, Yung Chang Chen^*

^*Corresponding author for this work

Department of Biomedical Sciences (Master's Program in Clinical Trials Assessment)

Research output: Contribution to journal › Journal Article › peer-review

41 Scopus citations

Abstract

Background/purpose: Indoxyl sulfate (IS) is a protein-binding molecule that exhibits cardiovascular (CV) toxicity. This study determined whether the serum IS level can be used to predict the risk of major adverse CV events (MACEs) in patients with chronic kidney disease (CKD). Methods: We studied 147 patients with CKD stage 1–5 over a 3-year follow-up period. IS was measured through mass spectrometry. Patients’ demographics were collected and analyzed to predict outcomes by using multivariable Cox regression. Results: Forty-seven (32.0%) patients had MACEs. IS remained significantly associated with MACEs after multivariable regression analysis. The area under the receiver operating characteristic curve for IS levels was 0.708 (95% confidence interval: 0.618–0.798). Conclusion: IS may have a critical role in the prediction of CV disease in patients with CKD. Further large-scale investigations are warranted and suggested.

Original language	English
Pages (from-to)	1099-1106
Number of pages	8
Journal	Journal of the Formosan Medical Association
Volume	118
Issue number	7
DOIs	https://doi.org/10.1016/j.jfma.2019.03.005
State	Published - 07 2019

Bibliographical note

Publisher Copyright:
© 2019 Formosan Medical Association

Keywords

Chronic kidney disease (CKD)
Indoxyl sulfate (IS)
Major adverse cardiovascular events (MACEs)
Prognosis
Protein-bound uremic toxins

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jfma.2019.03.005

Cite this

@article{c8eb54a4279f436296d68182c3713c20,

title = "Serum indoxyl sulfate predicts adverse cardiovascular events in patients with chronic kidney disease",

abstract = "Background/purpose: Indoxyl sulfate (IS) is a protein-binding molecule that exhibits cardiovascular (CV) toxicity. This study determined whether the serum IS level can be used to predict the risk of major adverse CV events (MACEs) in patients with chronic kidney disease (CKD). Methods: We studied 147 patients with CKD stage 1–5 over a 3-year follow-up period. IS was measured through mass spectrometry. Patients{\textquoteright} demographics were collected and analyzed to predict outcomes by using multivariable Cox regression. Results: Forty-seven (32.0\%) patients had MACEs. IS remained significantly associated with MACEs after multivariable regression analysis. The area under the receiver operating characteristic curve for IS levels was 0.708 (95\% confidence interval: 0.618–0.798). Conclusion: IS may have a critical role in the prediction of CV disease in patients with CKD. Further large-scale investigations are warranted and suggested.",

keywords = "Chronic kidney disease (CKD), Indoxyl sulfate (IS), Major adverse cardiovascular events (MACEs), Prognosis, Protein-bound uremic toxins",

author = "Fan, \{Pei Chun\} and Chang, \{Jason Chih Hsiang\} and Lin, \{Chia Ni\} and Lee, \{Cheng Chia\} and Chen, \{Yi Ting\} and Chu, \{Pao Hsien\} and George Kou and Lu, \{Yueh An\} and Yang, \{Chih Wei\} and Chen, \{Yung Chang\}",

note = "Publisher Copyright: {\textcopyright} 2019 Formosan Medical Association",

year = "2019",

month = jul,

doi = "10.1016/j.jfma.2019.03.005",

language = "英语",

volume = "118",

pages = "1099--1106",

journal = "Journal of the Formosan Medical Association",

issn = "0929-6646",

publisher = "Elsevier B.V.",

number = "7",

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TY - JOUR

T1 - Serum indoxyl sulfate predicts adverse cardiovascular events in patients with chronic kidney disease

AU - Fan, Pei Chun

AU - Chang, Jason Chih Hsiang

AU - Lin, Chia Ni

AU - Lee, Cheng Chia

AU - Chen, Yi Ting

AU - Chu, Pao Hsien

AU - Kou, George

AU - Lu, Yueh An

AU - Yang, Chih Wei

AU - Chen, Yung Chang

PY - 2019/7

Y1 - 2019/7

N2 - Background/purpose: Indoxyl sulfate (IS) is a protein-binding molecule that exhibits cardiovascular (CV) toxicity. This study determined whether the serum IS level can be used to predict the risk of major adverse CV events (MACEs) in patients with chronic kidney disease (CKD). Methods: We studied 147 patients with CKD stage 1–5 over a 3-year follow-up period. IS was measured through mass spectrometry. Patients’ demographics were collected and analyzed to predict outcomes by using multivariable Cox regression. Results: Forty-seven (32.0%) patients had MACEs. IS remained significantly associated with MACEs after multivariable regression analysis. The area under the receiver operating characteristic curve for IS levels was 0.708 (95% confidence interval: 0.618–0.798). Conclusion: IS may have a critical role in the prediction of CV disease in patients with CKD. Further large-scale investigations are warranted and suggested.

AB - Background/purpose: Indoxyl sulfate (IS) is a protein-binding molecule that exhibits cardiovascular (CV) toxicity. This study determined whether the serum IS level can be used to predict the risk of major adverse CV events (MACEs) in patients with chronic kidney disease (CKD). Methods: We studied 147 patients with CKD stage 1–5 over a 3-year follow-up period. IS was measured through mass spectrometry. Patients’ demographics were collected and analyzed to predict outcomes by using multivariable Cox regression. Results: Forty-seven (32.0%) patients had MACEs. IS remained significantly associated with MACEs after multivariable regression analysis. The area under the receiver operating characteristic curve for IS levels was 0.708 (95% confidence interval: 0.618–0.798). Conclusion: IS may have a critical role in the prediction of CV disease in patients with CKD. Further large-scale investigations are warranted and suggested.

KW - Chronic kidney disease (CKD)

KW - Indoxyl sulfate (IS)

KW - Major adverse cardiovascular events (MACEs)

KW - Prognosis

KW - Protein-bound uremic toxins

UR - https://www.scopus.com/pages/publications/85063407003

U2 - 10.1016/j.jfma.2019.03.005

DO - 10.1016/j.jfma.2019.03.005

M3 - 文章

C2 - 30928187

AN - SCOPUS:85063407003

SN - 0929-6646

VL - 118

SP - 1099

EP - 1106

JO - Journal of the Formosan Medical Association

JF - Journal of the Formosan Medical Association

IS - 7

ER -

Serum indoxyl sulfate predicts adverse cardiovascular events in patients with chronic kidney disease

Abstract

Bibliographical note

Keywords

UN SDGs

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