Serum level and prognostic value of neopterin in patients after ischemic stroke

Hung Sheng Lin, Tzu Hsien Tsai, Chu Feng Liu, Cheng Hsien Lu, Wen Neng Chang, Shu Feng Chen, Chi Wei Huang, Chi Ren Huang, Nai Wen Tsai, Chih Cheng Huang, Chia Wei Liou, Tsu Kung Lin, Min Yu Lan, Hon Kan Yip*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

21 Scopus citations

Abstract

Background: We hypothesized that serum level of neopterin is significantly predictive of prognostic outcome in patients after acute ischemic stroke (IS). Methods: Between November 2008 and May 2010, serum levels of neopterin were prospectively collected at 48. h after acute IS in 157 patients. Results: Serum neopterin levels were substantially higher in patients with severe neurological impairment [National institutes of Health Stroke Scale (NIHSS) score ≥. 12] than in those with NIHSS < 12 (p < 0.008). Furthermore, Spearman's test showed a strongly positive correlation between neopterin level and NIHSS (p = 0.003). Multiple logistic regression analysis demonstrated that serum neopterin level was strongly and independently predictive of NIHSS ≥. 12 (p = 0.002) at 48. h after acute IS and 90-day major adverse clinical outcome (defined as NIHSS. ≥. 12, recurrent stroke or death) (p = 0.003). Conclusion: Serum level of neopterin was notably increased after acute IS. This biomarker was strongly and independently predictive of 90-day unfavorable clinical outcome in patients after acute IS.

Original languageEnglish
Pages (from-to)1596-1601
Number of pages6
JournalClinical Biochemistry
Volume45
Issue number18
DOIs
StatePublished - 12 2012

Keywords

  • Ischemic stroke
  • Neopterin

Fingerprint

Dive into the research topics of 'Serum level and prognostic value of neopterin in patients after ischemic stroke'. Together they form a unique fingerprint.

Cite this