Sesquiterpenes from the rhizome of Curcuma longa with inhibitory activity on superoxide generation and elastase release by neutrophils

Jih Jung Chen*, Cheng Shuan Tsai, Tsong Long Hwang, Po Chuen Shieh, Jinn Fen Chen, Ping Jyun Sung

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

49 Scopus citations

Abstract

Six new sesquiterpenes, curculonone A (1), curculonone B (2), curculonone C (3), curculonone D (4), 6α-hydroxycurcumanolide A (5), and 1,10-dehydro-10-deoxy-9-oxozedoarondiol (6), have been isolated from the rhizome of Curcuma longa, together with 19 known compounds. The structures of these new compounds were determined through spectroscopic and MS analyses. Compounds 1, 2, 5, 12, 15, 16, and 23 exhibited inhibition (IC50 ≤ 18.22 μM) of superoxide anion generation by human neutrophils in response to formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B (fMLP/CB). Compounds 5, 12-16, and 23 inhibited fMLP/CB-induced elastase release with IC50 values ≤ 14.28 μM.

Original languageEnglish
Pages (from-to)974-980
Number of pages7
JournalFood Chemistry
Volume119
Issue number3
DOIs
StatePublished - 01 04 2010

Keywords

  • Curcuma longa
  • Inhibitory activity on neutrophil pro-inflammatory responses
  • Sesquiterpenes
  • Structure elucidation
  • Zingiberaceae

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