Sesquiterpenes from the rhizome of Curcuma longa with inhibitory activity on superoxide generation and elastase release by neutrophils

Jih Jung Chen; Cheng Shuan Tsai; Tsong Long Hwang; Po Chuen Shieh; Jinn Fen Chen; Ping Jyun Sung

doi:10.1016/j.foodchem.2009.07.060

Sesquiterpenes from the rhizome of Curcuma longa with inhibitory activity on superoxide generation and elastase release by neutrophils

Jih Jung Chen^*
, Cheng Shuan Tsai
, Tsong Long Hwang
, Po Chuen Shieh
, Jinn Fen Chen
, Ping Jyun Sung

^*Corresponding author for this work

School of Traditional Chinese Medicine

Tajen University
Taitung District Agricultural Research and Extension Station
National Museum of Marine Biology and Aquarium, Taiwan

Research output: Contribution to journal › Journal Article › peer-review

61 Scopus citations

Abstract

Six new sesquiterpenes, curculonone A (1), curculonone B (2), curculonone C (3), curculonone D (4), 6α-hydroxycurcumanolide A (5), and 1,10-dehydro-10-deoxy-9-oxozedoarondiol (6), have been isolated from the rhizome of Curcuma longa, together with 19 known compounds. The structures of these new compounds were determined through spectroscopic and MS analyses. Compounds 1, 2, 5, 12, 15, 16, and 23 exhibited inhibition (IC₅₀ ≤ 18.22 μM) of superoxide anion generation by human neutrophils in response to formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B (fMLP/CB). Compounds 5, 12-16, and 23 inhibited fMLP/CB-induced elastase release with IC₅₀ values ≤ 14.28 μM.

Original language	English
Pages (from-to)	974-980
Number of pages	7
Journal	Food Chemistry
Volume	119
Issue number	3
DOIs	https://doi.org/10.1016/j.foodchem.2009.07.060
State	Published - 01 04 2010

Keywords

Curcuma longa
Inhibitory activity on neutrophil pro-inflammatory responses
Sesquiterpenes
Structure elucidation
Zingiberaceae

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10.1016/j.foodchem.2009.07.060

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title = "Sesquiterpenes from the rhizome of Curcuma longa with inhibitory activity on superoxide generation and elastase release by neutrophils",

abstract = "Six new sesquiterpenes, curculonone A (1), curculonone B (2), curculonone C (3), curculonone D (4), 6α-hydroxycurcumanolide A (5), and 1,10-dehydro-10-deoxy-9-oxozedoarondiol (6), have been isolated from the rhizome of Curcuma longa, together with 19 known compounds. The structures of these new compounds were determined through spectroscopic and MS analyses. Compounds 1, 2, 5, 12, 15, 16, and 23 exhibited inhibition (IC50 ≤ 18.22 μM) of superoxide anion generation by human neutrophils in response to formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B (fMLP/CB). Compounds 5, 12-16, and 23 inhibited fMLP/CB-induced elastase release with IC50 values ≤ 14.28 μM.",

keywords = "Curcuma longa, Inhibitory activity on neutrophil pro-inflammatory responses, Sesquiterpenes, Structure elucidation, Zingiberaceae",

author = "Chen, \{Jih Jung\} and Tsai, \{Cheng Shuan\} and Hwang, \{Tsong Long\} and Shieh, \{Po Chuen\} and Chen, \{Jinn Fen\} and Sung, \{Ping Jyun\}",

year = "2010",

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doi = "10.1016/j.foodchem.2009.07.060",

language = "英语",

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T1 - Sesquiterpenes from the rhizome of Curcuma longa with inhibitory activity on superoxide generation and elastase release by neutrophils

AU - Chen, Jih Jung

AU - Tsai, Cheng Shuan

AU - Hwang, Tsong Long

AU - Shieh, Po Chuen

AU - Chen, Jinn Fen

AU - Sung, Ping Jyun

PY - 2010/4/1

Y1 - 2010/4/1

N2 - Six new sesquiterpenes, curculonone A (1), curculonone B (2), curculonone C (3), curculonone D (4), 6α-hydroxycurcumanolide A (5), and 1,10-dehydro-10-deoxy-9-oxozedoarondiol (6), have been isolated from the rhizome of Curcuma longa, together with 19 known compounds. The structures of these new compounds were determined through spectroscopic and MS analyses. Compounds 1, 2, 5, 12, 15, 16, and 23 exhibited inhibition (IC50 ≤ 18.22 μM) of superoxide anion generation by human neutrophils in response to formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B (fMLP/CB). Compounds 5, 12-16, and 23 inhibited fMLP/CB-induced elastase release with IC50 values ≤ 14.28 μM.

AB - Six new sesquiterpenes, curculonone A (1), curculonone B (2), curculonone C (3), curculonone D (4), 6α-hydroxycurcumanolide A (5), and 1,10-dehydro-10-deoxy-9-oxozedoarondiol (6), have been isolated from the rhizome of Curcuma longa, together with 19 known compounds. The structures of these new compounds were determined through spectroscopic and MS analyses. Compounds 1, 2, 5, 12, 15, 16, and 23 exhibited inhibition (IC50 ≤ 18.22 μM) of superoxide anion generation by human neutrophils in response to formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B (fMLP/CB). Compounds 5, 12-16, and 23 inhibited fMLP/CB-induced elastase release with IC50 values ≤ 14.28 μM.

KW - Curcuma longa

KW - Inhibitory activity on neutrophil pro-inflammatory responses

KW - Sesquiterpenes

KW - Structure elucidation

KW - Zingiberaceae

UR - https://www.scopus.com/pages/publications/70449094675

U2 - 10.1016/j.foodchem.2009.07.060

DO - 10.1016/j.foodchem.2009.07.060

M3 - 文章

AN - SCOPUS:70449094675

SN - 0308-8146

VL - 119

SP - 974

EP - 980

JO - Food Chemistry

JF - Food Chemistry

IS - 3

ER -

Sesquiterpenes from the rhizome of Curcuma longa with inhibitory activity on superoxide generation and elastase release by neutrophils

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Keywords

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