Seven new sesquiterpenoids from the fruits of Schisandra sphenanthera

Yao Ching Tsai; Yuan Bin Cheng; I. Wen Lo; Ho Hsi Cheng; Ching Jie Lin; Tsong Long Hwang; Yuh Chi Kuo; Shorong Shii Liou; Yi Zsau Huang; Yao Haur Kuo; Ya Ching Shen

doi:10.1002/cbdv.201300259

Seven new sesquiterpenoids from the fruits of Schisandra sphenanthera

Yao Ching Tsai, Yuan Bin Cheng, I. Wen Lo, Ho Hsi Cheng, Ching Jie Lin, Tsong Long Hwang, Yuh Chi Kuo, Shorong Shii Liou, Yi Zsau Huang, Yao Haur Kuo, Ya Ching Shen^*

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Article › peer-review

9 Scopus citations

Abstract

Fractionation of the EtOH extract from the fruits of Schisandra sphenanthera resulted in the isolation of seven new sesquiterpenoids, 1-7, in addition to the known metabolites 8-23. Among them, schiscupatetralin A (1) possesses an unprecedented structure with a C-C bond between cuparenol and tetralin. The isolated new compounds were evaluated for their anti-HSV-1 and anti-inflammatory activities. The results revealed that compound 4 exhibited anti-HSV-1 activity, while compound 6 showed a significant anti-inflammatory activity.

Original language	English
Pages (from-to)	1053-1068
Number of pages	16
Journal	Chemistry and Biodiversity
Volume	11
Issue number	7
DOIs	https://doi.org/10.1002/cbdv.201300259
State	Published - 07 2014

Keywords

Anti-HSV-1 activity
Anti-inflammatory activity
Schisandra sphenanthera
Sesquiterpenoids

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10.1002/cbdv.201300259

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title = "Seven new sesquiterpenoids from the fruits of Schisandra sphenanthera",

abstract = "Fractionation of the EtOH extract from the fruits of Schisandra sphenanthera resulted in the isolation of seven new sesquiterpenoids, 1-7, in addition to the known metabolites 8-23. Among them, schiscupatetralin A (1) possesses an unprecedented structure with a C-C bond between cuparenol and tetralin. The isolated new compounds were evaluated for their anti-HSV-1 and anti-inflammatory activities. The results revealed that compound 4 exhibited anti-HSV-1 activity, while compound 6 showed a significant anti-inflammatory activity.",

keywords = "Anti-HSV-1 activity, Anti-inflammatory activity, Schisandra sphenanthera, Sesquiterpenoids",

author = "Tsai, {Yao Ching} and Cheng, {Yuan Bin} and Lo, {I. Wen} and Cheng, {Ho Hsi} and Lin, {Ching Jie} and Hwang, {Tsong Long} and Kuo, {Yuh Chi} and Liou, {Shorong Shii} and Huang, {Yi Zsau} and Kuo, {Yao Haur} and Shen, {Ya Ching}",

year = "2014",

month = jul,

doi = "10.1002/cbdv.201300259",

language = "英语",

volume = "11",

pages = "1053--1068",

journal = "Chemistry and Biodiversity",

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AU - Tsai, Yao Ching

AU - Cheng, Yuan Bin

AU - Lo, I. Wen

AU - Cheng, Ho Hsi

AU - Lin, Ching Jie

AU - Hwang, Tsong Long

AU - Kuo, Yuh Chi

AU - Liou, Shorong Shii

AU - Huang, Yi Zsau

AU - Kuo, Yao Haur

AU - Shen, Ya Ching

PY - 2014/7

Y1 - 2014/7

N2 - Fractionation of the EtOH extract from the fruits of Schisandra sphenanthera resulted in the isolation of seven new sesquiterpenoids, 1-7, in addition to the known metabolites 8-23. Among them, schiscupatetralin A (1) possesses an unprecedented structure with a C-C bond between cuparenol and tetralin. The isolated new compounds were evaluated for their anti-HSV-1 and anti-inflammatory activities. The results revealed that compound 4 exhibited anti-HSV-1 activity, while compound 6 showed a significant anti-inflammatory activity.

AB - Fractionation of the EtOH extract from the fruits of Schisandra sphenanthera resulted in the isolation of seven new sesquiterpenoids, 1-7, in addition to the known metabolites 8-23. Among them, schiscupatetralin A (1) possesses an unprecedented structure with a C-C bond between cuparenol and tetralin. The isolated new compounds were evaluated for their anti-HSV-1 and anti-inflammatory activities. The results revealed that compound 4 exhibited anti-HSV-1 activity, while compound 6 showed a significant anti-inflammatory activity.

KW - Anti-HSV-1 activity

KW - Anti-inflammatory activity

KW - Schisandra sphenanthera

KW - Sesquiterpenoids

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JO - Chemistry and Biodiversity

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Seven new sesquiterpenoids from the fruits of Schisandra sphenanthera

Abstract

Keywords

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