Seven new sesquiterpenoids from the fruits of Schisandra sphenanthera

Yao Ching Tsai; Yuan Bin Cheng; I. Wen Lo; Ho Hsi Cheng; Ching Jie Lin; Tsong Long Hwang; Yuh Chi Kuo; Shorong Shii Liou; Yi Zsau Huang; Yao Haur Kuo; Ya Ching Shen

doi:10.1002/cbdv.201300259

Seven new sesquiterpenoids from the fruits of Schisandra sphenanthera

Yao Ching Tsai
, Yuan Bin Cheng
, I. Wen Lo
, Ho Hsi Cheng
, Ching Jie Lin
, Tsong Long Hwang
, Yuh Chi Kuo
, Shorong Shii Liou
, Yi Zsau Huang
, Yao Haur Kuo
, Ya Ching Shen^*

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Article › peer-review

9 Scopus citations

Abstract

Fractionation of the EtOH extract from the fruits of Schisandra sphenanthera resulted in the isolation of seven new sesquiterpenoids, 1-7, in addition to the known metabolites 8-23. Among them, schiscupatetralin A (1) possesses an unprecedented structure with a C-C bond between cuparenol and tetralin. The isolated new compounds were evaluated for their anti-HSV-1 and anti-inflammatory activities. The results revealed that compound 4 exhibited anti-HSV-1 activity, while compound 6 showed a significant anti-inflammatory activity.

Original language	English
Pages (from-to)	1053-1068
Number of pages	16
Journal	Chemistry and Biodiversity
Volume	11
Issue number	7
DOIs	https://doi.org/10.1002/cbdv.201300259
State	Published - 07 2014

Keywords

Anti-HSV-1 activity
Anti-inflammatory activity
Schisandra sphenanthera
Sesquiterpenoids

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10.1002/cbdv.201300259

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title = "Seven new sesquiterpenoids from the fruits of Schisandra sphenanthera",

abstract = "Fractionation of the EtOH extract from the fruits of Schisandra sphenanthera resulted in the isolation of seven new sesquiterpenoids, 1-7, in addition to the known metabolites 8-23. Among them, schiscupatetralin A (1) possesses an unprecedented structure with a C-C bond between cuparenol and tetralin. The isolated new compounds were evaluated for their anti-HSV-1 and anti-inflammatory activities. The results revealed that compound 4 exhibited anti-HSV-1 activity, while compound 6 showed a significant anti-inflammatory activity.",

keywords = "Anti-HSV-1 activity, Anti-inflammatory activity, Schisandra sphenanthera, Sesquiterpenoids",

author = "Tsai, \{Yao Ching\} and Cheng, \{Yuan Bin\} and Lo, \{I. Wen\} and Cheng, \{Ho Hsi\} and Lin, \{Ching Jie\} and Hwang, \{Tsong Long\} and Kuo, \{Yuh Chi\} and Liou, \{Shorong Shii\} and Huang, \{Yi Zsau\} and Kuo, \{Yao Haur\} and Shen, \{Ya Ching\}",

year = "2014",

month = jul,

doi = "10.1002/cbdv.201300259",

language = "英语",

volume = "11",

pages = "1053--1068",

journal = "Chemistry and Biodiversity",

issn = "1612-1872",

publisher = "Wiley-Blackwell",

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}

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T1 - Seven new sesquiterpenoids from the fruits of Schisandra sphenanthera

AU - Tsai, Yao Ching

AU - Cheng, Yuan Bin

AU - Lo, I. Wen

AU - Cheng, Ho Hsi

AU - Lin, Ching Jie

AU - Hwang, Tsong Long

AU - Kuo, Yuh Chi

AU - Liou, Shorong Shii

AU - Huang, Yi Zsau

AU - Kuo, Yao Haur

AU - Shen, Ya Ching

PY - 2014/7

Y1 - 2014/7

N2 - Fractionation of the EtOH extract from the fruits of Schisandra sphenanthera resulted in the isolation of seven new sesquiterpenoids, 1-7, in addition to the known metabolites 8-23. Among them, schiscupatetralin A (1) possesses an unprecedented structure with a C-C bond between cuparenol and tetralin. The isolated new compounds were evaluated for their anti-HSV-1 and anti-inflammatory activities. The results revealed that compound 4 exhibited anti-HSV-1 activity, while compound 6 showed a significant anti-inflammatory activity.

AB - Fractionation of the EtOH extract from the fruits of Schisandra sphenanthera resulted in the isolation of seven new sesquiterpenoids, 1-7, in addition to the known metabolites 8-23. Among them, schiscupatetralin A (1) possesses an unprecedented structure with a C-C bond between cuparenol and tetralin. The isolated new compounds were evaluated for their anti-HSV-1 and anti-inflammatory activities. The results revealed that compound 4 exhibited anti-HSV-1 activity, while compound 6 showed a significant anti-inflammatory activity.

KW - Anti-HSV-1 activity

KW - Anti-inflammatory activity

KW - Schisandra sphenanthera

KW - Sesquiterpenoids

UR - https://www.scopus.com/pages/publications/84904503623

U2 - 10.1002/cbdv.201300259

DO - 10.1002/cbdv.201300259

M3 - 文章

C2 - 25044591

AN - SCOPUS:84904503623

SN - 1612-1872

VL - 11

SP - 1053

EP - 1068

JO - Chemistry and Biodiversity

JF - Chemistry and Biodiversity

IS - 7

ER -

Seven new sesquiterpenoids from the fruits of Schisandra sphenanthera

Abstract

Keywords

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