Severe bronchopulmonary dysplasia is associated with higher fluid intake in very low-birth-weight infants: A retrospective study

Mindy Ming Huey Guo, Ching Hung Chung, Feng Shun Chen, Chih Cheng Chen, Hsin Chun Huang, Mei Yung Chung*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

20 Scopus citations

Abstract

Objective This study aims to investigate the association between fluid intake in the first 4 days of life and the subsequent severity of bronchopulmonary dysplasia (BPD) in very low-birth-weight infants (VLBWI). Study Design A retrospective chart review of 75 infants with a gestational age of less than 32 weeks and a birth weight of < 1,500 g was performed. Demographic, clinical data, associated maternal risk factors, and amount of fluid received in the first 4 days of life were analyzed. Results Severe BPD was associated with a lower gestational age (27.04 ± 2.073 wks vs. 28.70 ± 1.706 wks, p=0.001), lower birth weight (981.44 ± 244.54 vs. 1,199.63 ± 165.39 g, p < 0.001), use of surfactant (91.7 vs. 63%, p=0.002), patent ductus arteriousus (PDA) (70.8 vs. 37%, p=0.004), pulmonary hemorrhage (14.6 vs. 0%, p=0.045), and more fluids received from the 2nd to 4th days of life (346.44 ± 42.38 mL/kg vs. 323.91 ± 27.62 mL/kg, p=0.007). A cut off point of 345 mL/kg of fluids from the 2nd to 4th days of life was selected using receiver operating characteristic curve analysis, and remained a significant risk factor even after multiple logistic regression analysis.

Original languageEnglish
Pages (from-to)155-161
Number of pages7
JournalAmerican Journal of Perinatology
Volume30
Issue number2
DOIs
StatePublished - 02 2015

Bibliographical note

Publisher Copyright:
© 2015 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001,USA.

Keywords

  • bronchopulmonary dysplasia
  • fluid intake
  • patent ductus arteriosus
  • pulmonary hemorrhage
  • very low-birth-weight infants

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