Severity of hydronephrosis correlates with tumour invasiveness and urinary bladder recurrence of ureteric cancer

H.L. Luo, C.H. Kang, Yi-Ting Chen, Y.C. Chuang, W.C. Lee, Y.T. Cheng, P.H. Chiang

Research output: Contribution to journalJournal Article peer-review

8 Scopus citations

Abstract

Objectives To explore the prognostic role of hydronephrosis grade in patients with pure ureteric cancer. Patients and Methods The study included 162 patients with pure ureteric cancer who were treated between January 2005 and December 2010 at a single tertiary referral centre. The association between hydronephrosis grade with pathological findings and oncological outcomes was assessed using multivariate Cox regression analysis. Results Hydronephrosis grade >2 was independently associated with non-organ-confined ureteric cancer (P = 0.003). Hydronephrosis grade <2 was highly prevalent in organ-confined disease. Hydronephrosis grade >2 and bladder cancer history independently predict bladder cancer recurrence (P = 0.021 and P = 0.002, respectively) Hydronephrosis of grade >2 was found to be associated with local and distant recurrence only in univariate analysis; non-organ-confined pathology independently predicted local and distant oncological failure (P ≤ 0.001 and P = 0.002, respectively). Conclusions Hydronephrosis grade >2 is associated with non-organ-confined ureteric cancer and with bladder cancer recurrence. Non-organ-confined pathology is still the most important predictor for local and distant oncological failure. © 2013 BJU International.
Original languageAmerican English
Pages (from-to)489-494
JournalBJU International
Volume112
Issue number4
DOIs
StatePublished - 2013

Keywords

  • bladder recurrence
  • hydronephrosis
  • oncologic outcome
  • organ confined
  • predictive factor
  • ureteric cancer

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