Shock wave therapy effectively attenuates inflammation in rat carotid artery following endothelial denudation by balloon catheter

Pei Lin Shao, Chaw Chi Chiu, Chun Man Yuen, Sarah Chua, Li Teh Chang, Jiunn Jye Sheu, Cheuk Kwan Sun, Chiung Jen Wu, Ching Jen Wang, Hon Kan Yip*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

34 Scopus citations

Abstract

Background: This study investigates the effectiveness of extracorporeal shock wave (ECSW) in ameliorating inflammatory mediator expression and neointimal formation in a rat model of vascular injury. Methods and Results: Male Sprague-Dawley rats with left carotid artery (LCA) injury induced by balloon dilatation (BD; group 1) were compared with group 2 [LCA injury plus ECSW-181 (defined as 181 total shocks given in LCA at 0.011 mJ/mm2) on day 2 post-LCA injury], and group 3 (normal controls). The rats in each group were further divided into 3 subgroups (n = 6, each) that were sacrificed on postoperative day 3, 7 and 14, respectively. The results demonstrated that, compared to groups 2 and 3, group 1 had significantly increased cellular expression of CD40, interleukin-18, and connexin 43 at each analyzed time point (all p < 0.001). Additionally, LCCA macrophage (CD68) recruitment was substantially increased in group 1 compared to groups 2 and 3 (all p < 0.001). Furthermore, LCA neointimal proliferation and media thickness were markedly higher in group 1 than in groups 2 and 3 on days 7 and 14 post-BD (all p < 0.001). Conclusions: ECSW markedly attenuates inflammatory responses, proliferation of neointima and smooth muscle cells in a rat vascular injury model.

Original languageEnglish
Pages (from-to)130-144
Number of pages15
JournalCardiology
Volume115
Issue number2
DOIs
StatePublished - 01 2010

Keywords

  • Inflammatory mediators
  • Neointimal proliferation
  • Shock wave therapy
  • Vascular injury

Fingerprint

Dive into the research topics of 'Shock wave therapy effectively attenuates inflammation in rat carotid artery following endothelial denudation by balloon catheter'. Together they form a unique fingerprint.

Cite this