Short report: Coinfection with leptospirosis and scrub typhus in Taiwanese patients

Chen Hsiang Lee, Jien Wei Liu*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

34 Scopus citations


We retrospectively analyzed patients with leptospirosis (n = 35), scrub typhus (n = 45), and coinfection (leptospirosis and scrub typhus [n = 7]) to facilitate the detection of coinfection. Our data showed that factors favoring these disease entities included animal contact, an aspartate aminotransferase/alanine aminotransferase ratio > 2 (for leptospirosis); outdoor exposure, lymphadenopathy, splenomegaly, eschar, and elevated alkaline phosphatase levels (for scrub typhus and coinfection); calf tenderness, conjunctival suffusion, jaundice, oliguria, elevated total bilirubin levels and serum creatinine levels (for leptospirosis and coinfection); and maculopapular rash (for scrub typhus). Patients at risk for leptospirosis are often at increased risk for scrub typhus and vice versa. Lack of knowledge of coinfection may jeopardize the health of affected patients. Our study serves as a reminder of potential coinfection and provides clues for its detection.

Original languageEnglish
Pages (from-to)525-527
Number of pages3
JournalAmerican Journal of Tropical Medicine and Hygiene
Issue number3
StatePublished - 09 2007


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