Significance of Vitamin D Receptor Gene Polymorphisms for Risk of Hepatocellular Carcinoma in Chronic Hepatitis C

Chao-Hung Hung, Yi-Chun Chiu, Tsung-Hui Hu, Chien-Hung Chen, Sheng-Nan Lu, Chao-Min Huang, Jing-Houng Wang, Chuan-mo Lee

Research output: Contribution to journalJournal Article peer-review

31 Scopus citations

Abstract

BACKGROUND/AIMS: Biological and epidemiological data suggest that vitamin D levels may influence cancer development. Several single nucleotide polymorphisms have been described in the vitamin D receptor (VDR) gene in association with cancer risk. We aimed to investigate the association of VDR gene polymorphisms with hepatocellular carcinoma (HCC) development in chronic hepatitis C patients. METHODS: In a cross-sectional, hospital-based setting, 340 patients (201 chronic hepatitis, 47 cirrhosis and 92 HCC) and 100 healthy controls receiving VDR genotyping (bat-haplotype: BsmI rs1544410 C, ApaI rs7975232 C and TaqI rs731236 A) were enrolled. RESULTS: Patients with HCC had a higher frequency of ApaI CC genotype (P = 0.027) and bAt[CCA]-haplotype (P = 0.037) as compared to control subjects. There were no differences in BsmI and TaqI polymorphisms between two groups. In patients with chronic hepatitis C, HCC subjects had a higher frequency of ApaI CC genotype and bAt[CCA]-haplotype than those with chronic hepatitis (P = 0.001 and 0.002, respectively) and cirrhosis (P = 0.019 and 0.026, respectively). After adjusting age and sex, logistic regression analysis showed that ApaI CC genotype (odds ratio: 3.02, 95% confident interval: 1.65-5.51) was independently associated with HCC development. CONCLUSION: VDR ApaI polymorphism plays a role in the development of HCC among chronic hepatitis C patients. Further explorations of this finding and its implications are required.
Original languageAmerican English
Pages (from-to)503-507
JournalTranslational Oncology
Volume7
Issue number4
DOIs
StatePublished - 2014

Keywords

  • ASSOCIATION
  • AUTOIMMUNE HEPATITIS
  • CANCER-RISK
  • D INSUFFICIENCY
  • FIBROSIS
  • METAANALYSIS
  • NATURAL-HISTORY
  • PREDICTORS
  • PRIMARY BILIARY-CIRRHOSIS
  • PROGRESSION

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