Simulation of multi-photon emission isotopes using time-resolved SimSET multiple photon history generator

Chih Chieh Chiang; Hsin Hon Lin; Chang Shiun Lin; Meei Ling Jan; Keh Shih Chuang

doi:10.1109/ANIMMA.2015.7465629

Simulation of multi-photon emission isotopes using time-resolved SimSET multiple photon history generator

Chih Chieh Chiang, Hsin Hon Lin, Chang Shiun Lin, Meei Ling Jan, Keh Shih Chuang

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

1 Scopus citations

Abstract

Multiple-photon emitters, such as In-111 or Se-75, have enormous potential in the field of nuclear medicine imaging. For example, Se-75 can be used to investigate the bile acid malabsorption and measure the bile acid pool loss. The simulation system for emission tomography (SimSET) is a well-known Monte Carlo simulation (MCS) code in nuclear medicine for its high computational efficiency. However, current SimSET cannot simulate these isotopes due to the lack of modeling of complex decay scheme and the time-dependent decay process. To extend the versatility of SimSET for simulation of those multi-photon emission isotopes, a time-resolved multiple photon history generator based on SimSET codes is developed in present study. For developing the time-resolved SimSET (trSimSET) with radionuclide decay process, the new MCS model introduce new features, including decay time information and photon time-of-flight information, into this new code. The half-life of energy states were tabulated from the Evaluated Nuclear Structure Data File (ENSDF) database. The MCS results indicate that the overall percent difference is less than 6.1% for all simulation trials as compared to GATE. To sum up, we demonstrated that time-resolved SimSET multiple photon history generator can have comparable accuracy with GATE and keeping better computational efficiency. The new MCS code is very useful to study the multi-photon imaging of novel isotopes that needs the simulation of lifetime and the time-of-flight measurements.

Original language	English
Title of host publication	2015 4th International Conference on Advancements in Nuclear Instrumentation Measurement Methods and their Applications, ANIMMA 2015
Publisher	Institute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)	9781479999187
DOIs	https://doi.org/10.1109/ANIMMA.2015.7465629
State	Published - 2015
Externally published	Yes
Event	4th International Conference on Advancements in Nuclear Instrumentation Measurement Methods and their Applications, ANIMMA 2015 - Lisbon, Portugal Duration: 20 04 2015 → 24 04 2015

Publication series

Name	2015 4th International Conference on Advancements in Nuclear Instrumentation Measurement Methods and their Applications, ANIMMA 2015

Conference

Conference	4th International Conference on Advancements in Nuclear Instrumentation Measurement Methods and their Applications, ANIMMA 2015
Country/Territory	Portugal
City	Lisbon
Period	20/04/15 → 24/04/15

Bibliographical note

Publisher Copyright:
© 2015 IEEE.

Keywords

Monte Carlo Simulation (MCS)
multi-photon emission isotope
time-resolved SimSET

Access to Document

10.1109/ANIMMA.2015.7465629

Cite this

Chiang, C. C., Lin, H. H., Lin, C. S., Jan, M. L., & Chuang, K. S. (2015). Simulation of multi-photon emission isotopes using time-resolved SimSET multiple photon history generator. In 2015 4th International Conference on Advancements in Nuclear Instrumentation Measurement Methods and their Applications, ANIMMA 2015 Article 7465629 (2015 4th International Conference on Advancements in Nuclear Instrumentation Measurement Methods and their Applications, ANIMMA 2015). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/ANIMMA.2015.7465629

Chiang, Chih Chieh ; Lin, Hsin Hon ; Lin, Chang Shiun et al. / Simulation of multi-photon emission isotopes using time-resolved SimSET multiple photon history generator. 2015 4th International Conference on Advancements in Nuclear Instrumentation Measurement Methods and their Applications, ANIMMA 2015. Institute of Electrical and Electronics Engineers Inc., 2015. (2015 4th International Conference on Advancements in Nuclear Instrumentation Measurement Methods and their Applications, ANIMMA 2015).

@inproceedings{584324fde98043eeba7daf722e4734a4,

title = "Simulation of multi-photon emission isotopes using time-resolved SimSET multiple photon history generator",

abstract = "Multiple-photon emitters, such as In-111 or Se-75, have enormous potential in the field of nuclear medicine imaging. For example, Se-75 can be used to investigate the bile acid malabsorption and measure the bile acid pool loss. The simulation system for emission tomography (SimSET) is a well-known Monte Carlo simulation (MCS) code in nuclear medicine for its high computational efficiency. However, current SimSET cannot simulate these isotopes due to the lack of modeling of complex decay scheme and the time-dependent decay process. To extend the versatility of SimSET for simulation of those multi-photon emission isotopes, a time-resolved multiple photon history generator based on SimSET codes is developed in present study. For developing the time-resolved SimSET (trSimSET) with radionuclide decay process, the new MCS model introduce new features, including decay time information and photon time-of-flight information, into this new code. The half-life of energy states were tabulated from the Evaluated Nuclear Structure Data File (ENSDF) database. The MCS results indicate that the overall percent difference is less than 6.1% for all simulation trials as compared to GATE. To sum up, we demonstrated that time-resolved SimSET multiple photon history generator can have comparable accuracy with GATE and keeping better computational efficiency. The new MCS code is very useful to study the multi-photon imaging of novel isotopes that needs the simulation of lifetime and the time-of-flight measurements.",

keywords = "Monte Carlo Simulation (MCS), multi-photon emission isotope, time-resolved SimSET",

author = "Chiang, {Chih Chieh} and Lin, {Hsin Hon} and Lin, {Chang Shiun} and Jan, {Meei Ling} and Chuang, {Keh Shih}",

note = "Publisher Copyright: {\textcopyright} 2015 IEEE.; 4th International Conference on Advancements in Nuclear Instrumentation Measurement Methods and their Applications, ANIMMA 2015 ; Conference date: 20-04-2015 Through 24-04-2015",

year = "2015",

doi = "10.1109/ANIMMA.2015.7465629",

language = "英语",

series = "2015 4th International Conference on Advancements in Nuclear Instrumentation Measurement Methods and their Applications, ANIMMA 2015",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

booktitle = "2015 4th International Conference on Advancements in Nuclear Instrumentation Measurement Methods and their Applications, ANIMMA 2015",

address = "美国",

}

Chiang, CC, Lin, HH, Lin, CS, Jan, ML & Chuang, KS 2015, Simulation of multi-photon emission isotopes using time-resolved SimSET multiple photon history generator. in 2015 4th International Conference on Advancements in Nuclear Instrumentation Measurement Methods and their Applications, ANIMMA 2015., 7465629, 2015 4th International Conference on Advancements in Nuclear Instrumentation Measurement Methods and their Applications, ANIMMA 2015, Institute of Electrical and Electronics Engineers Inc., 4th International Conference on Advancements in Nuclear Instrumentation Measurement Methods and their Applications, ANIMMA 2015, Lisbon, Portugal, 20/04/15. https://doi.org/10.1109/ANIMMA.2015.7465629

Simulation of multi-photon emission isotopes using time-resolved SimSET multiple photon history generator. / Chiang, Chih Chieh; Lin, Hsin Hon; Lin, Chang Shiun et al.
2015 4th International Conference on Advancements in Nuclear Instrumentation Measurement Methods and their Applications, ANIMMA 2015. Institute of Electrical and Electronics Engineers Inc., 2015. 7465629 (2015 4th International Conference on Advancements in Nuclear Instrumentation Measurement Methods and their Applications, ANIMMA 2015).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Simulation of multi-photon emission isotopes using time-resolved SimSET multiple photon history generator

AU - Chiang, Chih Chieh

AU - Lin, Hsin Hon

AU - Lin, Chang Shiun

AU - Jan, Meei Ling

AU - Chuang, Keh Shih

PY - 2015

Y1 - 2015

N2 - Multiple-photon emitters, such as In-111 or Se-75, have enormous potential in the field of nuclear medicine imaging. For example, Se-75 can be used to investigate the bile acid malabsorption and measure the bile acid pool loss. The simulation system for emission tomography (SimSET) is a well-known Monte Carlo simulation (MCS) code in nuclear medicine for its high computational efficiency. However, current SimSET cannot simulate these isotopes due to the lack of modeling of complex decay scheme and the time-dependent decay process. To extend the versatility of SimSET for simulation of those multi-photon emission isotopes, a time-resolved multiple photon history generator based on SimSET codes is developed in present study. For developing the time-resolved SimSET (trSimSET) with radionuclide decay process, the new MCS model introduce new features, including decay time information and photon time-of-flight information, into this new code. The half-life of energy states were tabulated from the Evaluated Nuclear Structure Data File (ENSDF) database. The MCS results indicate that the overall percent difference is less than 6.1% for all simulation trials as compared to GATE. To sum up, we demonstrated that time-resolved SimSET multiple photon history generator can have comparable accuracy with GATE and keeping better computational efficiency. The new MCS code is very useful to study the multi-photon imaging of novel isotopes that needs the simulation of lifetime and the time-of-flight measurements.

AB - Multiple-photon emitters, such as In-111 or Se-75, have enormous potential in the field of nuclear medicine imaging. For example, Se-75 can be used to investigate the bile acid malabsorption and measure the bile acid pool loss. The simulation system for emission tomography (SimSET) is a well-known Monte Carlo simulation (MCS) code in nuclear medicine for its high computational efficiency. However, current SimSET cannot simulate these isotopes due to the lack of modeling of complex decay scheme and the time-dependent decay process. To extend the versatility of SimSET for simulation of those multi-photon emission isotopes, a time-resolved multiple photon history generator based on SimSET codes is developed in present study. For developing the time-resolved SimSET (trSimSET) with radionuclide decay process, the new MCS model introduce new features, including decay time information and photon time-of-flight information, into this new code. The half-life of energy states were tabulated from the Evaluated Nuclear Structure Data File (ENSDF) database. The MCS results indicate that the overall percent difference is less than 6.1% for all simulation trials as compared to GATE. To sum up, we demonstrated that time-resolved SimSET multiple photon history generator can have comparable accuracy with GATE and keeping better computational efficiency. The new MCS code is very useful to study the multi-photon imaging of novel isotopes that needs the simulation of lifetime and the time-of-flight measurements.

KW - Monte Carlo Simulation (MCS)

KW - multi-photon emission isotope

KW - time-resolved SimSET

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PB - Institute of Electrical and Electronics Engineers Inc.

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Chiang CC, Lin HH, Lin CS, Jan ML, Chuang KS. Simulation of multi-photon emission isotopes using time-resolved SimSET multiple photon history generator. In 2015 4th International Conference on Advancements in Nuclear Instrumentation Measurement Methods and their Applications, ANIMMA 2015. Institute of Electrical and Electronics Engineers Inc. 2015. 7465629. (2015 4th International Conference on Advancements in Nuclear Instrumentation Measurement Methods and their Applications, ANIMMA 2015). doi: 10.1109/ANIMMA.2015.7465629

Simulation of multi-photon emission isotopes using time-resolved SimSET multiple photon history generator

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