Simvastatin-Loaded Nanofibrous Membrane Efficiency on the Repair of Achilles Tendons

Chun Jui Weng, Chieh Tun Liao, Ming Yi Hsu, Fu Pang Chang, Shih Jung Liu*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

7 Scopus citations


Introduction: In this study, simvastatin-incorporated poly(D,L-lactide-co-glycolide) (PLGA) nanofibrous mats were fabricated via electrospinning, and their efficacy in the repair of the Achilles tendon was evaluated. Methods: The morphology of spun nanofibers and the in vitro drug release kinetics were assessed, while the in vivo efficacy in tendon repair was tested using a rat model. Results: Images obtained by scanning electron microscopy revealed that spun nanofibers exhibit a porous structure with a fiber diameter of approximately 350 nm. Fourier-transform infrared spectrometry and differential scanning calorimetry demonstrated successful incorporation of pharmaceutical agents into the PLGA nanofibers. The drug-loaded nanofibrous membranes sustainably discharged high concentrations of simvastatin for >28 days at the target site, and drug concentrations in blood were low. Tendons repaired using simvastatin-eluting nanofibers exhibited superior mechanical strength and animal activities to those repaired without nanofibers or with pure PLGA nanofibers. Discussion: Simvastatin-loaded nanofibers demonstrated effectiveness and sustainable capability for the repair of Achilles tendons. Eventually biodegradable drug-eluting nanofibrous mats may be used in humans for the treatment of tendon ruptures.

Original languageEnglish
Pages (from-to)1171-1184
Number of pages14
JournalInternational Journal of Nanomedicine
StatePublished - 2022

Bibliographical note

Publisher Copyright:
© 2022 Weng et al.


  • nanofibers
  • simvastatin
  • sustainable release
  • tendon repair


Dive into the research topics of 'Simvastatin-Loaded Nanofibrous Membrane Efficiency on the Repair of Achilles Tendons'. Together they form a unique fingerprint.

Cite this