Single vs. two steroid injections for carpal tunnel syndrome: A randomised clinical trial

S. M. Wong, Andrew C.F. Hui*, S. K. Lo, J. H. Chiu, W. F. Poon, L. Wong

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

37 Scopus citations


We investigated the efficacy of a single vs. double steroid injections in the treatment of carpal tunnel syndrome (CTS) in a randomised double-blind controlled trial. Patients with idiopathic CTS were randomised into (i) one group receiving a baseline methylprednisolone acetate injection plus a saline injection 8 weeks later and (ii) a second group receiving methylprednisolone acetate injection at baseline and at 8 weeks. The primary outcome was the Global Symptom Score (GSS). Forty patients were recruited. By 40 weeks, the mean GSS improved from 25.6 to 14.1 in the single-injection group whereas from 26.7 to 12.6 in the reinjection group, but there was no significant difference in GSS between the two groups (p = 0.26). There were also no significant differences in terms of electrophysiological and functional outcomes. The results suggest that an additional steroid injection confers no added benefit to a single injection in terms of symptom relief.

Original languageEnglish
Pages (from-to)1417-1421
Number of pages5
JournalInternational Journal of Clinical Practice
Issue number12
StatePublished - 12 2005
Externally publishedYes


  • Carpal tunnel syndrome
  • Randomised controlled trial
  • Steroid injection


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