Six-month angiographic study of immediate autologous bone marrow mononuclear cell implantation on acute anterior wall myocardial infarction using a mini-pig model

Jiunn Jye Sheu, Chun Man Yuen, Cheuk Kwan Sun, Li Teh Chang, Chia Hung Yen, Chiang Hua Chiang, Sheung Fat Ko, Sung Nan Pei, Sarah Chua, Anuj Bhasin, Chiung Jen Wu, Hon Kan Yip*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

4 Scopus citations

Abstract

This study investigated six-month angiographic results of autologous bone marrow mononuclear cell (BMMNC) transplantation immediately following acute myocardial infarction (AMI) in a mini-pig model. AMI was induced by left anterior descending artery ligation. Twenty-four mini-pigs were equally divided into group 1 [AMI plus saline injection in infarcted area (IA)], group 2 (AMI plus BMMNC transplantation into non-IA), group 3 (AMI plus BMMNC implantation into IA), and group 4 (sham control). One-week cultured BMMNCs (3.0 × 107) were immediately transplanted following AMI induction. Angiographic studies over 6 months demonstrated that mitral regurgitation (MR) was lower in groups 3 and 4 than in groups 1 and 2 (all P < 0.01). Wall motion scores and left ventricular ejection fraction (LVEF) were higher in groups 3 and 4 than in groups 1 and 2 (all P < 0.05). Collateral circulation was higher in group 3 than in groups 1 and 2 (P < 0.01). The wall thickness of the IA was higher, whereas the heart weight was lower in group 3 than in groups 1 and 2 (all P < 0.01). Immediate autologous BMMNC transplantation into IA is superior to saline-treated only or BMMNC transplantation into non-IA following AMI for reducing MR and improving LVEF.

Original languageEnglish
Pages (from-to)221-234
Number of pages14
JournalInternational Heart Journal
Volume50
Issue number2
DOIs
StatePublished - 2009

Keywords

  • Acute myocardial infarction
  • Angiographic studies
  • Bone-marrow cell transplantation
  • Mini-pig

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