Sleep disturbance and altered expression of circadian clock genes in patients with sudden sensorineural hearing loss

Chao-Hui Yang, Chung-Feng Hwang*, Pai Mei Lin, Jiin-Haur Chuang, Cheng Ming Hsu, Sheng Fung Lin, Ming Yu Yang

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

18 Scopus citations

Abstract

The cause of sudden sensorineural hearing loss (SSNHL) remains unclear and therefore it is often considered as idiopathic. Sleep disturbance has been linked to SSNHL and circadian rhythm disruption, but the link between circadian rhythm disruption and SSNHL has never been investigated. In this study, we surveyed the sleep quality of 38 patients with SSNHL using a simple insomnia sleep questionnaire. The expression of circadian clock genes in peripheral blood (PB) leukocytes from 38 patients with SSNHL and 71 healthy subjects was accessed using realtime quantitative reverse transcriptase-polymerase chain reaction and validated using immunocytochemical staining. We found that 61.8% of patients with SSNHL suffered from insomnia before the insult of hearing loss. Besides, significantly decreased expression of PER1, CRY1, CRY2, CLOCK, BMAL1, and CKle was found in PB leukocytes of patients with SSNHL when compared with healthy subjects. SSNHL patients with vertigo had significantly lower expression of CRY1 and CKle than patients without vertigo symptoms. Our results imply the association of sleep disturbance and disrupted circadian rhythm in SSNHL.

Original languageEnglish
Article numbere978
JournalMedicine (United States)
Volume94
Issue number26
DOIs
StatePublished - 01 07 2015

Bibliographical note

Publisher Copyright:
Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.

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