Smart multifunctional hollow microspheres for the quick release of drugs in intracellular lysosomal compartments

Cherng Jyh Ke; Tzu Yuan Su; Hsin Lung Chen; Hao Li Liu; Wei Lun Chiang; Po Chun Chu; Younan Xia; Hsing Wen Sung

doi:10.1002/anie.201102852

Smart multifunctional hollow microspheres for the quick release of drugs in intracellular lysosomal compartments

Cherng Jyh Ke, Tzu Yuan Su, Hsin Lung Chen, Hao Li Liu, Wei Lun Chiang, Po Chun Chu, Younan Xia^*, Hsing Wen Sung

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

138 Scopus citations

Abstract

Prepared to self-destruct: When poly(d,l-lactic-co-glycolic acid) (PLGA) hollow microspheres containing NaHCO₃ entered the endocytic organelles of a live cell, the NaHCO₃ in the aqueous core reacted with protons that infiltrated from the compartment to generate CO₂ gas. The evolution of CO₂ bubbles led to the formation of small holes in the PLGA shell and thus rapid release of the encapsulated drug doxorubicin (DOX; see picture).

Original language	English
Pages (from-to)	8086-8089
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	50
Issue number	35
DOIs	https://doi.org/10.1002/anie.201102852
State	Published - 22 08 2011
Externally published	Yes

Keywords

controlled release
double emulsions
drug delivery
fluorescence
multifunctional particles

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10.1002/anie.201102852

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title = "Smart multifunctional hollow microspheres for the quick release of drugs in intracellular lysosomal compartments",

abstract = "Prepared to self-destruct: When poly(d,l-lactic-co-glycolic acid) (PLGA) hollow microspheres containing NaHCO3 entered the endocytic organelles of a live cell, the NaHCO3 in the aqueous core reacted with protons that infiltrated from the compartment to generate CO2 gas. The evolution of CO2 bubbles led to the formation of small holes in the PLGA shell and thus rapid release of the encapsulated drug doxorubicin (DOX; see picture).",

keywords = "controlled release, double emulsions, drug delivery, fluorescence, multifunctional particles",

author = "Ke, \{Cherng Jyh\} and Su, \{Tzu Yuan\} and Chen, \{Hsin Lung\} and Liu, \{Hao Li\} and Chiang, \{Wei Lun\} and Chu, \{Po Chun\} and Younan Xia and Sung, \{Hsing Wen\}",

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AU - Ke, Cherng Jyh

AU - Su, Tzu Yuan

AU - Chen, Hsin Lung

AU - Liu, Hao Li

AU - Chiang, Wei Lun

AU - Chu, Po Chun

AU - Xia, Younan

AU - Sung, Hsing Wen

PY - 2011/8/22

Y1 - 2011/8/22

N2 - Prepared to self-destruct: When poly(d,l-lactic-co-glycolic acid) (PLGA) hollow microspheres containing NaHCO3 entered the endocytic organelles of a live cell, the NaHCO3 in the aqueous core reacted with protons that infiltrated from the compartment to generate CO2 gas. The evolution of CO2 bubbles led to the formation of small holes in the PLGA shell and thus rapid release of the encapsulated drug doxorubicin (DOX; see picture).

AB - Prepared to self-destruct: When poly(d,l-lactic-co-glycolic acid) (PLGA) hollow microspheres containing NaHCO3 entered the endocytic organelles of a live cell, the NaHCO3 in the aqueous core reacted with protons that infiltrated from the compartment to generate CO2 gas. The evolution of CO2 bubbles led to the formation of small holes in the PLGA shell and thus rapid release of the encapsulated drug doxorubicin (DOX; see picture).

KW - controlled release

KW - double emulsions

KW - drug delivery

KW - fluorescence

KW - multifunctional particles

UR - https://www.scopus.com/pages/publications/80051776168

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JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 35

ER -

Smart multifunctional hollow microspheres for the quick release of drugs in intracellular lysosomal compartments

Abstract

Keywords

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