SNP detection based on temperature-controllable EWOD digital microfluidics system

Hsien Hua Shen; Tsung Yao Su; Hwan You Chang; Da Jeng Yao

doi:10.1109/NMDC.2012.6527576

SNP detection based on temperature-controllable EWOD digital microfluidics system

Hsien Hua Shen
, Tsung Yao Su
, Hwan You Chang
, Da Jeng Yao^*

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

1 Scopus citations

Abstract

This study based on the technique, "Electrowetting on Dielectric (EWOD)," with the micro-heaters designed in EWOD microfluidics system for temperature controlling in biomedical reaction. On this platform, fluorescence magnetic beads (MBs) were used as carriers for single-nucleotide polymorphism (SNP) detection. In human genome, SNPs are responsible for the variations between individuals. The genome of a person comprise specific SNP could result in responsiveness to drug therapies and sensitivity of certain disease. Therefore, SNP is considered as one of the keys to predict the affect in pharmacogenomic medicine. In this study, SNP detection has been demonstrated on this thermal controllable EWOD platform in order to approach the goal of "lab-on-a-chip".

Original language	English
Title of host publication	2012 IEEE Nanotechnology Materials and Devices Conference, IEEE NMDC 2012
Pages	92-95
Number of pages	4
DOIs	https://doi.org/10.1109/NMDC.2012.6527576
State	Published - 2012
Externally published	Yes
Event	2012 IEEE Nanotechnology Materials and Devices Conference, IEEE NMDC 2012 - Waikiki Beach, HI, United States Duration: 16 10 2012 → 19 10 2012

Publication series

Name	2012 IEEE Nanotechnology Materials and Devices Conference, IEEE NMDC 2012

Conference

Conference	2012 IEEE Nanotechnology Materials and Devices Conference, IEEE NMDC 2012
Country/Territory	United States
City	Waikiki Beach, HI
Period	16/10/12 → 19/10/12

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10.1109/NMDC.2012.6527576

Cite this

@inproceedings{7b164837d9f34026911b1a23deaf7d66,

title = "SNP detection based on temperature-controllable EWOD digital microfluidics system",

abstract = "This study based on the technique, {"}Electrowetting on Dielectric (EWOD),{"} with the micro-heaters designed in EWOD microfluidics system for temperature controlling in biomedical reaction. On this platform, fluorescence magnetic beads (MBs) were used as carriers for single-nucleotide polymorphism (SNP) detection. In human genome, SNPs are responsible for the variations between individuals. The genome of a person comprise specific SNP could result in responsiveness to drug therapies and sensitivity of certain disease. Therefore, SNP is considered as one of the keys to predict the affect in pharmacogenomic medicine. In this study, SNP detection has been demonstrated on this thermal controllable EWOD platform in order to approach the goal of {"}lab-on-a-chip{"}.",

author = "Shen, \{Hsien Hua\} and Su, \{Tsung Yao\} and Chang, \{Hwan You\} and Yao, \{Da Jeng\}",

year = "2012",

doi = "10.1109/NMDC.2012.6527576",

language = "英语",

isbn = "9781467328708",

series = "2012 IEEE Nanotechnology Materials and Devices Conference, IEEE NMDC 2012",

pages = "92--95",

booktitle = "2012 IEEE Nanotechnology Materials and Devices Conference, IEEE NMDC 2012",

note = "2012 IEEE Nanotechnology Materials and Devices Conference, IEEE NMDC 2012 ; Conference date: 16-10-2012 Through 19-10-2012",

}

Shen, HH, Su, TY, Chang, HY & Yao, DJ 2012, SNP detection based on temperature-controllable EWOD digital microfluidics system. in 2012 IEEE Nanotechnology Materials and Devices Conference, IEEE NMDC 2012., 6527576, 2012 IEEE Nanotechnology Materials and Devices Conference, IEEE NMDC 2012, pp. 92-95, 2012 IEEE Nanotechnology Materials and Devices Conference, IEEE NMDC 2012, Waikiki Beach, HI, United States, 16/10/12. https://doi.org/10.1109/NMDC.2012.6527576

SNP detection based on temperature-controllable EWOD digital microfluidics system. / Shen, Hsien Hua; Su, Tsung Yao; Chang, Hwan You et al.
2012 IEEE Nanotechnology Materials and Devices Conference, IEEE NMDC 2012. 2012. p. 92-95 6527576 (2012 IEEE Nanotechnology Materials and Devices Conference, IEEE NMDC 2012).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - SNP detection based on temperature-controllable EWOD digital microfluidics system

AU - Shen, Hsien Hua

AU - Su, Tsung Yao

AU - Chang, Hwan You

AU - Yao, Da Jeng

PY - 2012

Y1 - 2012

N2 - This study based on the technique, "Electrowetting on Dielectric (EWOD)," with the micro-heaters designed in EWOD microfluidics system for temperature controlling in biomedical reaction. On this platform, fluorescence magnetic beads (MBs) were used as carriers for single-nucleotide polymorphism (SNP) detection. In human genome, SNPs are responsible for the variations between individuals. The genome of a person comprise specific SNP could result in responsiveness to drug therapies and sensitivity of certain disease. Therefore, SNP is considered as one of the keys to predict the affect in pharmacogenomic medicine. In this study, SNP detection has been demonstrated on this thermal controllable EWOD platform in order to approach the goal of "lab-on-a-chip".

AB - This study based on the technique, "Electrowetting on Dielectric (EWOD)," with the micro-heaters designed in EWOD microfluidics system for temperature controlling in biomedical reaction. On this platform, fluorescence magnetic beads (MBs) were used as carriers for single-nucleotide polymorphism (SNP) detection. In human genome, SNPs are responsible for the variations between individuals. The genome of a person comprise specific SNP could result in responsiveness to drug therapies and sensitivity of certain disease. Therefore, SNP is considered as one of the keys to predict the affect in pharmacogenomic medicine. In this study, SNP detection has been demonstrated on this thermal controllable EWOD platform in order to approach the goal of "lab-on-a-chip".

UR - https://www.scopus.com/pages/publications/84880115290

U2 - 10.1109/NMDC.2012.6527576

DO - 10.1109/NMDC.2012.6527576

M3 - 会议稿件

AN - SCOPUS:84880115290

SN - 9781467328708

T3 - 2012 IEEE Nanotechnology Materials and Devices Conference, IEEE NMDC 2012

SP - 92

EP - 95

BT - 2012 IEEE Nanotechnology Materials and Devices Conference, IEEE NMDC 2012

T2 - 2012 IEEE Nanotechnology Materials and Devices Conference, IEEE NMDC 2012

Y2 - 16 October 2012 through 19 October 2012

ER -

SNP detection based on temperature-controllable EWOD digital microfluidics system

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