Solanum lyratum extract inhibits Helicobacter pylori-mediated apoptosis in human gastric epithelial cells

Yuan Man Hsu; Chih Ho Lai; Chiu Hsiang Su; Wei Wen Kuo; Chao Lin Kuo; Cheng Kuang Hsu; Chien Kuo Wang; Ching Yao Chang; Jing Gung Chung

Solanum lyratum extract inhibits Helicobacter pylori-mediated apoptosis in human gastric epithelial cells

Yuan Man Hsu, Chih Ho Lai, Chiu Hsiang Su, Wei Wen Kuo, Chao Lin Kuo, Cheng Kuang Hsu, Chien Kuo Wang, Ching Yao Chang, Jing Gung Chung^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

6 Scopus citations

Abstract

Helicobacter pylori infection is associated with chronic gastritis, peptic ulcers, and gastric cancer. The effects of Solanum lyratum extract (SLE) on anti-H. pylori activity and H. pylori-induced apoptosis were investigated. SLE showed a moderate ability in inhibiting growth of H. pylori and also in interrupting the association of bacteria with host cells. SLE was also able to suppress H. pylori-induced apoptosis. SLE inhibited caspase-8 activation, thereby preventing the release of cytochrome c from mitochondria and activation of the subsequent downstream apoptotic pathway. Thus, SLE may offer a new approach for the treatment of H. pylori by down-regulation of apoptosis in the H. pylori infected gastric epithelium. As it does not directly target bacteria, SLE treatment might not cause development of resistant strains.

Original language	English
Pages (from-to)	1189-1193
Number of pages	5
Journal	Anticancer Research
Volume	30
Issue number	4
State	Published - 04 2010
Externally published	Yes

Keywords

Apoptosis
Helicobacter pylori
Human gastric epithelial cells
Solanum lyratum

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "Solanum lyratum extract inhibits Helicobacter pylori-mediated apoptosis in human gastric epithelial cells",

abstract = "Helicobacter pylori infection is associated with chronic gastritis, peptic ulcers, and gastric cancer. The effects of Solanum lyratum extract (SLE) on anti-H. pylori activity and H. pylori-induced apoptosis were investigated. SLE showed a moderate ability in inhibiting growth of H. pylori and also in interrupting the association of bacteria with host cells. SLE was also able to suppress H. pylori-induced apoptosis. SLE inhibited caspase-8 activation, thereby preventing the release of cytochrome c from mitochondria and activation of the subsequent downstream apoptotic pathway. Thus, SLE may offer a new approach for the treatment of H. pylori by down-regulation of apoptosis in the H. pylori infected gastric epithelium. As it does not directly target bacteria, SLE treatment might not cause development of resistant strains.",

keywords = "Apoptosis, Helicobacter pylori, Human gastric epithelial cells, Solanum lyratum",

author = "Hsu, {Yuan Man} and Lai, {Chih Ho} and Su, {Chiu Hsiang} and Kuo, {Wei Wen} and Kuo, {Chao Lin} and Hsu, {Cheng Kuang} and Wang, {Chien Kuo} and Chang, {Ching Yao} and Chung, {Jing Gung}",

year = "2010",

month = apr,

language = "英语",

volume = "30",

pages = "1189--1193",

journal = "Anticancer Research",

issn = "0250-7005",

publisher = "International Institute of Anticancer Research",

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}

TY - JOUR

T1 - Solanum lyratum extract inhibits Helicobacter pylori-mediated apoptosis in human gastric epithelial cells

AU - Hsu, Yuan Man

AU - Lai, Chih Ho

AU - Su, Chiu Hsiang

AU - Kuo, Wei Wen

AU - Kuo, Chao Lin

AU - Hsu, Cheng Kuang

AU - Wang, Chien Kuo

AU - Chang, Ching Yao

AU - Chung, Jing Gung

PY - 2010/4

Y1 - 2010/4

N2 - Helicobacter pylori infection is associated with chronic gastritis, peptic ulcers, and gastric cancer. The effects of Solanum lyratum extract (SLE) on anti-H. pylori activity and H. pylori-induced apoptosis were investigated. SLE showed a moderate ability in inhibiting growth of H. pylori and also in interrupting the association of bacteria with host cells. SLE was also able to suppress H. pylori-induced apoptosis. SLE inhibited caspase-8 activation, thereby preventing the release of cytochrome c from mitochondria and activation of the subsequent downstream apoptotic pathway. Thus, SLE may offer a new approach for the treatment of H. pylori by down-regulation of apoptosis in the H. pylori infected gastric epithelium. As it does not directly target bacteria, SLE treatment might not cause development of resistant strains.

AB - Helicobacter pylori infection is associated with chronic gastritis, peptic ulcers, and gastric cancer. The effects of Solanum lyratum extract (SLE) on anti-H. pylori activity and H. pylori-induced apoptosis were investigated. SLE showed a moderate ability in inhibiting growth of H. pylori and also in interrupting the association of bacteria with host cells. SLE was also able to suppress H. pylori-induced apoptosis. SLE inhibited caspase-8 activation, thereby preventing the release of cytochrome c from mitochondria and activation of the subsequent downstream apoptotic pathway. Thus, SLE may offer a new approach for the treatment of H. pylori by down-regulation of apoptosis in the H. pylori infected gastric epithelium. As it does not directly target bacteria, SLE treatment might not cause development of resistant strains.

KW - Apoptosis

KW - Helicobacter pylori

KW - Human gastric epithelial cells

KW - Solanum lyratum

UR - http://www.scopus.com/inward/record.url?scp=77953797737&partnerID=8YFLogxK

M3 - 文章

C2 - 20530426

AN - SCOPUS:77953797737

SN - 0250-7005

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EP - 1193

JO - Anticancer Research

JF - Anticancer Research

IS - 4

ER -

Solanum lyratum extract inhibits Helicobacter pylori-mediated apoptosis in human gastric epithelial cells

Abstract

Keywords

UN SDGs

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