Solitary fibrous tumor of the abdominal wall: A report of two cases with immunohistochemical, flow cytometric, and ultrastructural studies and literature review

Hsuan Ying Huang, Ming Tse Sung, Hock Liew Eng, Timothy Yc Lee, Sheung Fat Ko, Chih Chi Wang, Wei Jen Chen*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

27 Scopus citations

Abstract

Solitary fibrous tumors have been described at many extrapleural sites in recent years. However, solitary fibrous tumors arising from somatic soft tissue occur only rarely and can pose problems in the differential diagnosis from other benign or malignant soft tissue tumors. The majority of solitary fibrous tumors occurring in the somatic soft tissue have been found in the extremities and limb girdles, and the head and neck regions. There have been only eight published cases located in the abdominal wall. We herein report two female patients who developed solitary fibrous tumors of the abdominal wall that were not in association with the underlying peritoneum. Histologically, both tumors were characterized by a variety of architectural patterns, alternating hypercellular and hypocellular areas, proliferation of plump spindle cells, thick keloid-like and/or amianthoid collagen bundles, and ectatic staghorn-like vessels. Both tumors showed a diffuse strong reaction for CD34 and vimentin as well as focal positivity for bcl-2 and smooth muscle actin. A striking predominance in females was found in a literature review of solitary fibrous tumors of the abdominal wall, contrasting with other somatic soft tissue sites which show an equal gender distribution. Interestingly, expression of estrogen but not progesterone receptor was observed in both tumors. Ultrastructurally, the tumor cells displayed features of fibroblasts with dilated branching rough endoplasmic reticulum (RER) and Golgi apparatus. Both tumors assayed by flow cytometry demonstrated a diploid DNA content with an S-phase fraction of 7.9% and 11.4%, respectively. At follow up, both patients were well without evidence of recurrence or metastasis after surgical excision.

Original languageEnglish
Pages (from-to)253-262
Number of pages10
JournalAPMIS
Volume110
Issue number3
DOIs
StatePublished - 2002
Externally publishedYes

Keywords

  • Abdominal wall
  • CD34
  • Estrogen receptor
  • Female
  • Solitary fibrous tumor
  • Somatic soft tissue

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