Spinal cord localization of the motoneurons innervating the sacrococcygeus dorsi lateralis muscle and their noradrenergic nerve terminals in rats

Ping Wing Lui; Gwo Jyh Chang; Tak Yu Lee; Samuel H.H. Chan

doi:10.1016/0304-3940(93)90527-R

Spinal cord localization of the motoneurons innervating the sacrococcygeus dorsi lateralis muscle and their noradrenergic nerve terminals in rats

Ping Wing Lui, Gwo Jyh Chang, Tak Yu Lee, Samuel H.H. Chan^*

^*Corresponding author for this work

Veterans General Hospital-Taipei

Research output: Contribution to journal › Journal Article › peer-review

4 Scopus citations

Abstract

We examined in the present study the spinal cord localization of motoneurons innervating the caudal portion of the sacrococcygeus dorsi lateralis (SCDL) muscle and their noradrenergic nerve terminals in Sprague-Dawley rats, using horseradish peroxidase (HRP) and dopamine-β-hydroxylase (DBH) double-labeling techniques. Retrogradely HRP-labeled motoneurons innervating the caudal part of the SCDL muscle were located ipsilaterally in the ventromedial aspect of the ventral horn (lamina IX) in spinal segments of S₂-S₄. These cells were polygonal in shape, with an average soma diameter of 37.0 ± 1.1 μm (mean ± S.E.M., n = 95) and amounted to 33.6 ± 5.7 (n = 7) in the horizontal plane. Of note was the presence of abundant DBH-positive nerve terminals arborizing on the soma and dendrites of HRP-labeled motoneurons. These results provided anatomical evidence to further support our previous findings that the coerulospinal noradrenergic neurotransmission is involved in the mediation of fentanyl-induced muscular rigidity.

Original language	English
Pages (from-to)	165-168
Number of pages	4
Journal	Neuroscience Letters
Volume	150
Issue number	2
DOIs	https://doi.org/10.1016/0304-3940(93)90527-R
State	Published - 19 02 1993
Externally published	Yes

Keywords

Dopamine-β-hydroxylase
Horseadish peroxidase
Motoneuron
Noradrenergic nerve terminal
Rat
Sacrococcygeus dorsi lateralis muscle
Spinal cord

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10.1016/0304-3940(93)90527-R

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title = "Spinal cord localization of the motoneurons innervating the sacrococcygeus dorsi lateralis muscle and their noradrenergic nerve terminals in rats",

abstract = "We examined in the present study the spinal cord localization of motoneurons innervating the caudal portion of the sacrococcygeus dorsi lateralis (SCDL) muscle and their noradrenergic nerve terminals in Sprague-Dawley rats, using horseradish peroxidase (HRP) and dopamine-β-hydroxylase (DBH) double-labeling techniques. Retrogradely HRP-labeled motoneurons innervating the caudal part of the SCDL muscle were located ipsilaterally in the ventromedial aspect of the ventral horn (lamina IX) in spinal segments of S2-S4. These cells were polygonal in shape, with an average soma diameter of 37.0 ± 1.1 μm (mean ± S.E.M., n = 95) and amounted to 33.6 ± 5.7 (n = 7) in the horizontal plane. Of note was the presence of abundant DBH-positive nerve terminals arborizing on the soma and dendrites of HRP-labeled motoneurons. These results provided anatomical evidence to further support our previous findings that the coerulospinal noradrenergic neurotransmission is involved in the mediation of fentanyl-induced muscular rigidity.",

keywords = "Dopamine-β-hydroxylase, Horseadish peroxidase, Motoneuron, Noradrenergic nerve terminal, Rat, Sacrococcygeus dorsi lateralis muscle, Spinal cord",

author = "Lui, {Ping Wing} and Chang, {Gwo Jyh} and Lee, {Tak Yu} and Chan, {Samuel H.H.}",

year = "1993",

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T1 - Spinal cord localization of the motoneurons innervating the sacrococcygeus dorsi lateralis muscle and their noradrenergic nerve terminals in rats

AU - Lui, Ping Wing

AU - Chang, Gwo Jyh

AU - Lee, Tak Yu

AU - Chan, Samuel H.H.

PY - 1993/2/19

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N2 - We examined in the present study the spinal cord localization of motoneurons innervating the caudal portion of the sacrococcygeus dorsi lateralis (SCDL) muscle and their noradrenergic nerve terminals in Sprague-Dawley rats, using horseradish peroxidase (HRP) and dopamine-β-hydroxylase (DBH) double-labeling techniques. Retrogradely HRP-labeled motoneurons innervating the caudal part of the SCDL muscle were located ipsilaterally in the ventromedial aspect of the ventral horn (lamina IX) in spinal segments of S2-S4. These cells were polygonal in shape, with an average soma diameter of 37.0 ± 1.1 μm (mean ± S.E.M., n = 95) and amounted to 33.6 ± 5.7 (n = 7) in the horizontal plane. Of note was the presence of abundant DBH-positive nerve terminals arborizing on the soma and dendrites of HRP-labeled motoneurons. These results provided anatomical evidence to further support our previous findings that the coerulospinal noradrenergic neurotransmission is involved in the mediation of fentanyl-induced muscular rigidity.

AB - We examined in the present study the spinal cord localization of motoneurons innervating the caudal portion of the sacrococcygeus dorsi lateralis (SCDL) muscle and their noradrenergic nerve terminals in Sprague-Dawley rats, using horseradish peroxidase (HRP) and dopamine-β-hydroxylase (DBH) double-labeling techniques. Retrogradely HRP-labeled motoneurons innervating the caudal part of the SCDL muscle were located ipsilaterally in the ventromedial aspect of the ventral horn (lamina IX) in spinal segments of S2-S4. These cells were polygonal in shape, with an average soma diameter of 37.0 ± 1.1 μm (mean ± S.E.M., n = 95) and amounted to 33.6 ± 5.7 (n = 7) in the horizontal plane. Of note was the presence of abundant DBH-positive nerve terminals arborizing on the soma and dendrites of HRP-labeled motoneurons. These results provided anatomical evidence to further support our previous findings that the coerulospinal noradrenergic neurotransmission is involved in the mediation of fentanyl-induced muscular rigidity.

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KW - Horseadish peroxidase

KW - Motoneuron

KW - Noradrenergic nerve terminal

KW - Rat

KW - Sacrococcygeus dorsi lateralis muscle

KW - Spinal cord

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JO - Neuroscience Letters

JF - Neuroscience Letters

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Spinal cord localization of the motoneurons innervating the sacrococcygeus dorsi lateralis muscle and their noradrenergic nerve terminals in rats

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Keywords

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