Staphylococcus aureus exotoxin has limited and transient effects on cochlear electrophysiology

Wey Jim Hsu, Matti Anniko, Takeshi Kubo, Monica Lundholm, Tsun Sheng Huang

Research output: Contribution to journalJournal Article peer-review

2 Scopus citations

Abstract

Seven ears of Sprague-Dawley rats were exposed to 20 μl Staphylococcus aureus exotoxin suspension by injection via the tympanic membrane into the round window niche. Another 6 ears were exposed to 20 μl broth as controls. ABR was performed in the interval 2-31.5 kHz immediately before and 1, 2, 5, 7 and 10 days after the exposure. Although threshold changes could be found in the toxin-exposed group but not the control group in the frequency range 10-20 kHz, there were only statistically significant threshold changes at 31.5 kHz - on the 1st, 2nd, 5th, and 7th days after the exotoxin injection. S. aureus exotoxin has minor transient but reversible effects on the inner ear, causing chiefly high-frequency threshold and latency changes.

Original languageEnglish
Pages (from-to)12-17
Number of pages6
JournalORL
Volume60
Issue number1
DOIs
StatePublished - 01 1998
Externally publishedYes

Keywords

  • Auditory brainstem response
  • Cochlea
  • Function
  • Round window
  • Toxin

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