Steroidal and α-tocopherylhydroquinone glycosides from two soft corals Cladiella hirsuta and Sinularia nanolobata

Chih Hua Chao; Tzu Zin Huang; Chia Yun Wu; Bo Wei Chen; Chiung Yao Huang; Tsong Long Hwang; Chang Feng Dai; Jyh Horng Sheu

doi:10.1039/c5ra13436f

Steroidal and α-tocopherylhydroquinone glycosides from two soft corals Cladiella hirsuta and Sinularia nanolobata

Chih Hua Chao
, Tzu Zin Huang
, Chia Yun Wu
, Bo Wei Chen
, Chiung Yao Huang
, Tsong Long Hwang
, Chang Feng Dai
, Jyh Horng Sheu^*

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Article › peer-review

18 Scopus citations

Abstract

Two new pregnane glycosides, hirsutosterosides A and B (1 and 2), as well as two new α-tocopherylhydroquinone glycosides, cladophenol glycosides A and B (3 and 4) were isolated from a soft coral Cladiella hirsuta. In addition, a new steroidal glycoside, lobatasteroside A (5) along with six known steroids (6-11), were discovered from the other soft coral Sinularia nanolobata. Their structures were elucidated by extensive spectroscopic analysis. Cytotoxicities of the isolates against a limited panel of cancer cell lines were reported. The inhibitory activities for superoxide anion generation and elastase release for these compounds were also examined to evaluate the anti-inflammatory potential.

Original language	English
Pages (from-to)	74256-74262
Number of pages	7
Journal	RSC Advances
Volume	5
Issue number	91
DOIs	https://doi.org/10.1039/c5ra13436f
State	Published - 24 08 2015

Bibliographical note

Publisher Copyright:
© 2015 The Royal Society of Chemistry.

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title = "Steroidal and α-tocopherylhydroquinone glycosides from two soft corals Cladiella hirsuta and Sinularia nanolobata",

abstract = "Two new pregnane glycosides, hirsutosterosides A and B (1 and 2), as well as two new α-tocopherylhydroquinone glycosides, cladophenol glycosides A and B (3 and 4) were isolated from a soft coral Cladiella hirsuta. In addition, a new steroidal glycoside, lobatasteroside A (5) along with six known steroids (6-11), were discovered from the other soft coral Sinularia nanolobata. Their structures were elucidated by extensive spectroscopic analysis. Cytotoxicities of the isolates against a limited panel of cancer cell lines were reported. The inhibitory activities for superoxide anion generation and elastase release for these compounds were also examined to evaluate the anti-inflammatory potential.",

author = "Chao, \{Chih Hua\} and Huang, \{Tzu Zin\} and Wu, \{Chia Yun\} and Chen, \{Bo Wei\} and Huang, \{Chiung Yao\} and Hwang, \{Tsong Long\} and Dai, \{Chang Feng\} and Sheu, \{Jyh Horng\}",

note = "Publisher Copyright: {\textcopyright} 2015 The Royal Society of Chemistry.",

year = "2015",

month = aug,

day = "24",

doi = "10.1039/c5ra13436f",

language = "英语",

volume = "5",

pages = "74256--74262",

journal = "RSC Advances",

issn = "2046-2069",

publisher = "Royal Society of Chemistry",

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}

TY - JOUR

T1 - Steroidal and α-tocopherylhydroquinone glycosides from two soft corals Cladiella hirsuta and Sinularia nanolobata

AU - Chao, Chih Hua

AU - Huang, Tzu Zin

AU - Wu, Chia Yun

AU - Chen, Bo Wei

AU - Huang, Chiung Yao

AU - Hwang, Tsong Long

AU - Dai, Chang Feng

AU - Sheu, Jyh Horng

PY - 2015/8/24

Y1 - 2015/8/24

N2 - Two new pregnane glycosides, hirsutosterosides A and B (1 and 2), as well as two new α-tocopherylhydroquinone glycosides, cladophenol glycosides A and B (3 and 4) were isolated from a soft coral Cladiella hirsuta. In addition, a new steroidal glycoside, lobatasteroside A (5) along with six known steroids (6-11), were discovered from the other soft coral Sinularia nanolobata. Their structures were elucidated by extensive spectroscopic analysis. Cytotoxicities of the isolates against a limited panel of cancer cell lines were reported. The inhibitory activities for superoxide anion generation and elastase release for these compounds were also examined to evaluate the anti-inflammatory potential.

AB - Two new pregnane glycosides, hirsutosterosides A and B (1 and 2), as well as two new α-tocopherylhydroquinone glycosides, cladophenol glycosides A and B (3 and 4) were isolated from a soft coral Cladiella hirsuta. In addition, a new steroidal glycoside, lobatasteroside A (5) along with six known steroids (6-11), were discovered from the other soft coral Sinularia nanolobata. Their structures were elucidated by extensive spectroscopic analysis. Cytotoxicities of the isolates against a limited panel of cancer cell lines were reported. The inhibitory activities for superoxide anion generation and elastase release for these compounds were also examined to evaluate the anti-inflammatory potential.

UR - https://www.scopus.com/pages/publications/84941236837

U2 - 10.1039/c5ra13436f

DO - 10.1039/c5ra13436f

M3 - 文章

AN - SCOPUS:84941236837

SN - 2046-2069

VL - 5

SP - 74256

EP - 74262

JO - RSC Advances

JF - RSC Advances

IS - 91

ER -

Steroidal and α-tocopherylhydroquinone glycosides from two soft corals Cladiella hirsuta and Sinularia nanolobata

Abstract

Bibliographical note

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