Sterols from the octocoral Nephthea columnaris

Ta Yuan Whuang; Hong Chieh Tsai; Yin Di Su; Tsong Long Hwang; Ping Jyun Sung

doi:10.3390/md15070212

Sterols from the octocoral Nephthea columnaris

Ta Yuan Whuang, Hong Chieh Tsai, Yin Di Su, Tsong Long Hwang^*, Ping Jyun Sung

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Article › peer-review

9 Scopus citations

Abstract

Two new sterols, columnaristerols B (1) and C (2), along with two known analogues, 5,6-epoxylitosterol (3) and litosterol (4), were obtained from the octocoral Nephthea columnaris. The structures of new sterols 1 and 2 were elucidated by using spectroscopic methods and comparing the spectroscopic data with those of known related metabolites. Sterol 3 was found to suppress superoxide anion production and elastase secretion by human neutrophils.

Original language	English
Article number	212
Journal	Marine Drugs
Volume	15
Issue number	7
DOIs	https://doi.org/10.3390/md15070212
State	Published - 07 2017

Bibliographical note

Publisher Copyright:
© 2017 by the authors. Licensee MDPI.

Keywords

Columnaristerol
Elastase
Litosterol
Nephthea columnaris
Octocoral
Superoxide anion

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title = "Sterols from the octocoral Nephthea columnaris",

abstract = "Two new sterols, columnaristerols B (1) and C (2), along with two known analogues, 5,6-epoxylitosterol (3) and litosterol (4), were obtained from the octocoral Nephthea columnaris. The structures of new sterols 1 and 2 were elucidated by using spectroscopic methods and comparing the spectroscopic data with those of known related metabolites. Sterol 3 was found to suppress superoxide anion production and elastase secretion by human neutrophils.",

keywords = "Columnaristerol, Elastase, Litosterol, Nephthea columnaris, Octocoral, Superoxide anion",

author = "Whuang, {Ta Yuan} and Tsai, {Hong Chieh} and Su, {Yin Di} and Hwang, {Tsong Long} and Sung, {Ping Jyun}",

note = "Publisher Copyright: {\textcopyright} 2017 by the authors. Licensee MDPI.",

year = "2017",

month = jul,

doi = "10.3390/md15070212",

language = "英语",

volume = "15",

journal = "Marine Drugs",

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T1 - Sterols from the octocoral Nephthea columnaris

AU - Whuang, Ta Yuan

AU - Tsai, Hong Chieh

AU - Su, Yin Di

AU - Hwang, Tsong Long

AU - Sung, Ping Jyun

PY - 2017/7

Y1 - 2017/7

N2 - Two new sterols, columnaristerols B (1) and C (2), along with two known analogues, 5,6-epoxylitosterol (3) and litosterol (4), were obtained from the octocoral Nephthea columnaris. The structures of new sterols 1 and 2 were elucidated by using spectroscopic methods and comparing the spectroscopic data with those of known related metabolites. Sterol 3 was found to suppress superoxide anion production and elastase secretion by human neutrophils.

AB - Two new sterols, columnaristerols B (1) and C (2), along with two known analogues, 5,6-epoxylitosterol (3) and litosterol (4), were obtained from the octocoral Nephthea columnaris. The structures of new sterols 1 and 2 were elucidated by using spectroscopic methods and comparing the spectroscopic data with those of known related metabolites. Sterol 3 was found to suppress superoxide anion production and elastase secretion by human neutrophils.

KW - Columnaristerol

KW - Elastase

KW - Litosterol

KW - Nephthea columnaris

KW - Octocoral

KW - Superoxide anion

UR - http://www.scopus.com/inward/record.url?scp=85024479690&partnerID=8YFLogxK

U2 - 10.3390/md15070212

DO - 10.3390/md15070212

M3 - 文章

C2 - 28677628

AN - SCOPUS:85024479690

SN - 1660-3397

VL - 15

JO - Marine Drugs

JF - Marine Drugs

IS - 7

M1 - 212

ER -

Sterols from the octocoral Nephthea columnaris

Abstract

Bibliographical note

Keywords

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