Abstract
Introduction: The clinical manifestations of cutaneous adverse drug reactions are variable with different severity. Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening severe cutaneous adverse reactions (SCARs) majorly caused by drugs and mediated by cytotoxic T cells. Areas covered: In this review, we focus on risk factors that contribute to the development of SJS/TEN and review the updated immune mechanism, preventive strategies as well as current therapeutic approaches for SJS/TEN. Expert opinion: The progress of SJS/TEN researches reveals that cytotoxic T cells majorly activated by drug interacted with the human leukocyte antigen (HLA) and T cell receptors play an important role for the immune mechanism of SJS/TEN. Several clinical assessment tools and in vitro drug-T cells activation tests have been developed to identify the causality of SJS/TEN. New therapeutic approaches and biologics such as TNF-alpha antagonist have been conducted to improve the prognosis of SJS/TEN.
| Original language | English |
|---|---|
| Pages (from-to) | 373-387 |
| Number of pages | 15 |
| Journal | Expert Review of Clinical Immunology |
| Volume | 16 |
| Issue number | 4 |
| DOIs | |
| State | Published - 02 04 2020 |
Bibliographical note
Publisher Copyright:© 2020, © 2020 Informa UK Limited, trading as Taylor & Francis Group.
Keywords
- Human leukocyte antigen (HLA)
- Stevens-Johnson syndrome (SJS)
- T cell receptors
- severe cutaneous adverse reactions
- toxic epidermal necrolysis (TEN)
