Stimulation of the subthalamic region at 20Hz slows the development of grip force in Parkinson's disease

Chiung Chu Chen*, Wey Yil Lin, Hsiao Lung Chan, Yi Ting Hsu, Po Hsun Tu, Shih-Tseng Lee, Shang Ming Chiou, Chon Haw Tsai, Chin-Song Lu, Peter Brown

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

46 Scopus citations

Abstract

Excessive synchronization of basal ganglia neuronal activity at ~ 20 Hz is characteristic of patients with untreated Parkinson's disease (PD). Correlative evidence suggests that this activity may contribute to bradykinesia. Attempts to demonstrate causality through stimulation imposed synchronization at 20. Hz in the region of the subthalamic nucleus (STN) have had limited success. Finger-tapping is slowed by about 8% and only in those PD patients that have a relatively normal baseline performance in this task. Here we investigate whether greater performance decrements might be seen in a reaction time grip task. We studied 32 sides in 16 patients with PD after overnight withdrawal of medication. Patients were asked to grip as hard and as fast as possible without STN stimulation and during bilateral stimulation at 5. Hz, 10. Hz, 20. Hz, 50. Hz and 130. Hz. Stimulation at 20. Hz slowed the development of force by 14.7 ± 8.3% (P=0.044) across all patients. Slowing increased by 22 ± 7% (P=0.005) in those patients with the best performance in the task without stimulation. The effect was frequency specific. These data provide direct interventional evidence of a mechanistic link between excessive neuronal synchronization in the beta range and motor impairment in PD.

Original languageEnglish
Pages (from-to)91-96
Number of pages6
JournalExperimental Neurology
Volume231
Issue number1
DOIs
StatePublished - 09 2011

Keywords

  • Basal ganglia
  • Beta activity
  • Deep brain stimulation
  • Grip force
  • Parkinson's disease

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