Structural covariance networks of striatum subdivision in patients with Parkinson's disease

Kun Hsien Chou, Wei Che Lin*, Pei Lin Lee, Nai Wen Tsai, Yung Cheng Huang, Hsiu Ling Chen, Kuei Yueh Cheng, Pei Chin Chen, Hung Chen Wang, Tsu Kung Lin, Shau Hsuan Li, Wei Ming Lin, Cheng Hsien Lu, Ching Po Lin

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

34 Scopus citations

Abstract

Parkinson's disease (PD) is a neurodegenerative disorder associated with the striatum. Previous studies indicated that subdivisions of the striatum with distinct functional connectivity profiles contribute to different pathogeneses in PD. Segregated structural covariance (SC) pattern between the striatum and neocortex observed in healthy subjects, however, remain unknown in PD. The purpose of this study is to map and compare the subregional striatal SC network organization between 30 healthy controls and 48 PD patients and to investigate their association with the disease severity. The striatal SC network was statistically inferred by correlating the mean gray matter (GM) volume of six striatal subdivisions (including the bilateral dorsal caudate, superior ventral striatum, inferior ventral striatum, dorsal caudal putamen, dorsal rostral putamen, and ventral rostral putamen) with the entire neocortical GM volume in voxel-wise manner. The PD patients revealed marked atrophy in the striatum, cerebellum, and extra-striatum neocortices. As predicted, segregated striatal SC network patterns were observed in both groups. This suggests that in PD, pathological processes occurring in the striatum affect the same striato-cortical networks that covary with the striatum in healthy brains. The PD patients further demonstrated atypical striatal SC patterns between the caudate, parahippocampus temporal cortices, and cerebellum, which corresponded to dopaminergic associated network. The areas with significant group differences in SC were further associated with disease severity. Our findings support previous studies indicating that PD is associated with altered striato-cortical networks, and suggest that structural changes in the striatum may result in a cascade of alterations in multiple neocortices. Hum Brain Mapp 36:1567-1584, 2015.

Original languageEnglish
Pages (from-to)1567-1584
Number of pages18
JournalHuman Brain Mapping
Volume36
Issue number4
DOIs
StatePublished - 01 04 2015

Bibliographical note

Publisher Copyright:
© 2014 Wiley Periodicals, Inc.

Keywords

  • Cerebellum
  • Connectivity
  • Dopamine
  • Magnetic resonance imaging
  • Movement disorder
  • Neuroplasticity
  • Subcortical

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