Study the effect of polymerization temperature in the release of antibiotic from bone cement

Ching Lung Tai, Siu Lian Tsai, Yu Han Chang, Pang Hsin Hsieh*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

4 Scopus citations

Abstract

Antibiotic-loaded bone cement is widely used to treat musculoskeletal infections. Here we tested whether the curing temperature affected pore size of the cement and antibiotic release. Bone cement containing vancomycin was cured at 3 temperatures (50, 25 and 0°C). The solidified vancomycin-loaded cement was stored for 1-week at 25 and 5°C and then assayed for antibiotic release. We found that a significantly higher proportion of vancomycin was released from cement cured at 0°C versus that cured at 50°C, and that lower storage temperature also increased antibiotic release.

Original languageEnglish
Pages (from-to)341-346
Number of pages6
JournalBio-Medical Materials and Engineering
Volume21
Issue number5-6
DOIs
StatePublished - 2011

Keywords

  • Bone cement
  • antibiotic
  • porosity
  • release
  • temperature

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