Successful pregnancy after preimplantation genetic diagnosis in a female with Robertsonian translocation

Yueh Chao Wu, Chun Kai Chen, Hong Yuan Huang*, Chi Ju Chou, Yung Kuei Soong

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

2 Scopus citations

Abstract

Preimplantation genetic diagnosis (PGD) is an alternative option for couples with chromosome abnormalities. A 34-year-old woman with balanced Robertsonian translocation [ (45, XX, der(13; 14) (q10; q10) ] requested PGD due to recurrent spontaneous abortion. Embryos of good quality were biopsied on day 3 post-oocyte retrieval. The aspirated blastomeres were fixed and analyzed using fluorescence in situ hybridization. In the first cycle, 2 unaffected embryos were transferred back without success. No unaffected embryo was available in the second cycle. On day 5 in the third cycle, 2 unaffected embryos were transferred resulting in a twin pregnancy. Amniocentesis confirmed the diagnosis. At the gestational age of 35 weeks, 2 healthy girls were born via cesarean section. Postnatal physical examination found no evidence of major abnormalities.

Original languageEnglish
Pages (from-to)637-639
Number of pages3
JournalJournal of the Formosan Medical Association
Volume103
Issue number8
StatePublished - 08 2004
Externally publishedYes

Keywords

  • Case reports
  • Fluorescence in situ hybridization
  • Preimplantation diagnosis
  • Translocation (genetics)

Fingerprint

Dive into the research topics of 'Successful pregnancy after preimplantation genetic diagnosis in a female with Robertsonian translocation'. Together they form a unique fingerprint.

Cite this