Successful transplantation of ethnically mismatched cord blood in a boy with atypical chronic myeloid leukemia

Tang Her Jaing*, Iou Jih Hung, Shih Hsiang Chen, Wen I. Lee, Yu Chuan Wen, En Chen Fang

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

1 Scopus citations

Abstract

In the present study, we describe unrelated umbilical cord blood transplantation (CBT) in a 7-year-old Taiwanese boy with atypical chronic myeloid leukemia (BCR-ABL 1 negative). Physical examination was notable for splenomegaly. Cytogenetic analyses from the bone marrow revealed a t(3;5)(p21;q31) translocation. The patient then underwent CBT from an HLA-mismatched (two loci by serotype, three loci by genotype) unrelated donor of Caucasian origin. Times to neutrophil and platelet engraftment were 21 and 62 days post-transplant, respectively. Acute graft-versus-host disease following transplantation was minimal. The patient remains in continuing hematological remission with full donor chimerism 28 months after transplantation.

Original languageEnglish
Pages (from-to)144-146
Number of pages3
JournalInternational Journal of Hematology
Volume97
Issue number1
DOIs
StatePublished - 01 2013

Keywords

  • Atypical chronic myeloid leukemia
  • Cytogenetic analyses
  • Unrelated cord blood transplantation

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