Successful Treatment of Refractory Status Epilepticus Using Anterior Thalamic Nuclei Deep Brain Stimulation

Ching Yi Lee, Siew Na Lim, Tony Wu, Shih Tseng Lee*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

35 Scopus citations


Background Refractory status epilepticus (RSE) is considered a medical emergency in neurology and is related to high mortality. We report a successfully treated case of RSE using deep brain stimulation (DBS) at the anterior thalamic nuclei (ATN) in a 17-year-old woman. Results This patient developed RSE as a result of progressive seizure activity. RSE with generalized tonic-clonic seizures was noted 2 weeks before admission. Video electroencephalography monitoring showed continuous 3-Hz generalized spike-and-wave complexes with higher amplitude over bilateral frontal. Four weeks after RSE onset, bilateral DBS of the ATN was started. This treatment was immediately followed by the disappearance of tonic-clonic seizures and spike-and-wave complexes, suggesting resolution of the RSE. Significant clinical improvement was noted 1 week after DBS implantation. Conclusions DBS at the ATN significantly improved both the electroencephalography and clinical presentation in the patient with RSE. DBS at the ATN should be considered as a possible treatment choice once a patient develops RSE.

Original languageEnglish
Pages (from-to)14-18
Number of pages5
JournalWorld Neurosurgery
StatePublished - 01 03 2017

Bibliographical note

Publisher Copyright:
© 2016 The Authors


  • Anterior thalamic nucleus
  • Deep brain stimulation
  • Refractory status epilepticus


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