Abstract
謝格連氏症候群是一種合併乾眼症，口乾唾液分泌減少之自體免疫疾病，臨床上
除症狀治療外並無確定之治療模式。我們提出一位十七歲之女性病人，經診斷為系統性紅斑
性狼瘡合併狼瘡性腎炎及謝格連氏症候群，在使用 cyclophosphamide 脈衝式療法之後，乾
眼症及唾液分泌功能皆獲致明顯之改善，而且比較小唾液腺組織切片在治療前後淋巴球浸潤
的情形，組織病理上也有明顯之進步。
The treatment of Sjogren's syndrome (SS) is very controversial, though several therapeutic regimens have been proposed. Cyclophosphamide pulse therapy has been widely used in many disease entities. However, reports concerning its clinical application in SS were very rare. We report a 17-year-old girl presenting with lupus nephritis and SS, which was refractory to corticosteroid therapy but successfully treated with cyclophosphamide pulse therapy. The improvement of clinical features was confirmed by Schirmer's test and minor salivary gland biopsy.
The treatment of Sjogren's syndrome (SS) is very controversial, though several therapeutic regimens have been proposed. Cyclophosphamide pulse therapy has been widely used in many disease entities. However, reports concerning its clinical application in SS were very rare. We report a 17-year-old girl presenting with lupus nephritis and SS, which was refractory to corticosteroid therapy but successfully treated with cyclophosphamide pulse therapy. The improvement of clinical features was confirmed by Schirmer's test and minor salivary gland biopsy.
| Original language | American English |
|---|---|
| Pages (from-to) | 268 |
| Journal | 中華民國小兒科醫學會雜誌 |
| Volume | 39 |
| Issue number | 4 |
| State | Published - 1998 |