Abstract
A 19-month-old boy with chronic granulomatous disease (CGD) received umbilical cord blood transplantation (UCBT) from an unrelated donor after experiencing a life-threatening disseminated Bacillus Calmette-Guérin infection. After busulfan and cyclophosphamide conditioning, we performed a 5/6-matched UCBT. Engraftment and mixed chimerism was 100% in peripheral blood, and 100% of his neutrophils had normal oxidative burst activity on day 17. The patient is now 3 years old, free from infection, and growing well. To our knowledge, this is the second case of CGD treated with UCBT in Taiwan. His successful outcome illustrates that UCBT in a patient with CGD should be considered early if a human leukocyte antigen-matched donor is not available or the patient has just recovered from a severe infection.
Original language | English |
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Pages (from-to) | 346-350 |
Number of pages | 5 |
Journal | Pediatrics and Neonatology |
Volume | 56 |
Issue number | 5 |
DOIs | |
State | Published - 10 2015 |
Bibliographical note
Publisher Copyright:Copyright © 2015, Taiwan Pediatric Association. Published by Elsevier Taiwan LLC. All rights reserved.
Keywords
- chronic granulomatous disease (CGD)
- disseminated Bacillus Calmette-Guérin (BCG) infection
- umbilical cord blood transplantation (UCBT)