Successful Unrelated Cord Blood Stem Cell Transplantation in an X-linked Chronic Granulomatous Disease Patient with Disseminated BCG-induced Infection

Chao Jen Lin*, Shih Chung Wang, Cheng Lung Ku, Jun Kai Kao, Ming Chen, Chin San Liu

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

13 Scopus citations

Abstract

A 19-month-old boy with chronic granulomatous disease (CGD) received umbilical cord blood transplantation (UCBT) from an unrelated donor after experiencing a life-threatening disseminated Bacillus Calmette-Guérin infection. After busulfan and cyclophosphamide conditioning, we performed a 5/6-matched UCBT. Engraftment and mixed chimerism was 100% in peripheral blood, and 100% of his neutrophils had normal oxidative burst activity on day 17. The patient is now 3 years old, free from infection, and growing well. To our knowledge, this is the second case of CGD treated with UCBT in Taiwan. His successful outcome illustrates that UCBT in a patient with CGD should be considered early if a human leukocyte antigen-matched donor is not available or the patient has just recovered from a severe infection.

Original languageEnglish
Pages (from-to)346-350
Number of pages5
JournalPediatrics and Neonatology
Volume56
Issue number5
DOIs
StatePublished - 10 2015

Bibliographical note

Publisher Copyright:
Copyright © 2015, Taiwan Pediatric Association. Published by Elsevier Taiwan LLC. All rights reserved.

Keywords

  • chronic granulomatous disease (CGD)
  • disseminated Bacillus Calmette-Guérin (BCG) infection
  • umbilical cord blood transplantation (UCBT)

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