Successful unrelated donor cord blood transplantation for chronic granulomatous disease

Tang Her Jaing; Wen I. Lee; Po Jen Cheng; Shih Hsiang Chen; Jing Long Huang; Yung Kuei Soong

doi:10.1007/s12185-010-0537-5

Successful unrelated donor cord blood transplantation for chronic granulomatous disease

Tang Her Jaing, Wen I. Lee, Po Jen Cheng, Shih Hsiang Chen, Jing Long Huang, Yung Kuei Soong^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

6 Scopus citations

Abstract

This report exemplified a success of unrelated donor cord blood transplantation (CBT) in a 4-month-old boy with chronic granulomatous disease (CGD). Following Bu14/Cy200/ATG conditioning, the patient received an HLA 2-locus-mismatched cord blood unit, and the total number of infused nucleated cells was 11.52 × 10⁷/kg. Neutrophil engraftment was achieved on day +13, and a platelet count greater than 20 × 10⁹/L was achieved on day ?50. The neutrophil oxidative burst was 100% normal with full donor lymphocyte reconstitution at 8 months post-transplant. This case highlights that unrelated donor CBT for CGD is potentially safe and feasible, even in early infancy, when an appropriately matched related or unrelated donor is unavailable.

Original language	English
Pages (from-to)	670-672
Number of pages	3
Journal	International Journal of Hematology
Volume	91
Issue number	4
DOIs	https://doi.org/10.1007/s12185-010-0537-5
State	Published - 05 2010

Keywords

Chronic granulomatous disease
Unrelated cord blood transplantation
Young infant

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10.1007/s12185-010-0537-5

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title = "Successful unrelated donor cord blood transplantation for chronic granulomatous disease",

abstract = "This report exemplified a success of unrelated donor cord blood transplantation (CBT) in a 4-month-old boy with chronic granulomatous disease (CGD). Following Bu14/Cy200/ATG conditioning, the patient received an HLA 2-locus-mismatched cord blood unit, and the total number of infused nucleated cells was 11.52 × 107/kg. Neutrophil engraftment was achieved on day +13, and a platelet count greater than 20 × 109/L was achieved on day ?50. The neutrophil oxidative burst was 100% normal with full donor lymphocyte reconstitution at 8 months post-transplant. This case highlights that unrelated donor CBT for CGD is potentially safe and feasible, even in early infancy, when an appropriately matched related or unrelated donor is unavailable.",

keywords = "Chronic granulomatous disease, Unrelated cord blood transplantation, Young infant",

author = "Jaing, {Tang Her} and Lee, {Wen I.} and Cheng, {Po Jen} and Chen, {Shih Hsiang} and Huang, {Jing Long} and Soong, {Yung Kuei}",

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T1 - Successful unrelated donor cord blood transplantation for chronic granulomatous disease

AU - Jaing, Tang Her

AU - Lee, Wen I.

AU - Cheng, Po Jen

AU - Chen, Shih Hsiang

AU - Huang, Jing Long

AU - Soong, Yung Kuei

PY - 2010/5

Y1 - 2010/5

N2 - This report exemplified a success of unrelated donor cord blood transplantation (CBT) in a 4-month-old boy with chronic granulomatous disease (CGD). Following Bu14/Cy200/ATG conditioning, the patient received an HLA 2-locus-mismatched cord blood unit, and the total number of infused nucleated cells was 11.52 × 107/kg. Neutrophil engraftment was achieved on day +13, and a platelet count greater than 20 × 109/L was achieved on day ?50. The neutrophil oxidative burst was 100% normal with full donor lymphocyte reconstitution at 8 months post-transplant. This case highlights that unrelated donor CBT for CGD is potentially safe and feasible, even in early infancy, when an appropriately matched related or unrelated donor is unavailable.

AB - This report exemplified a success of unrelated donor cord blood transplantation (CBT) in a 4-month-old boy with chronic granulomatous disease (CGD). Following Bu14/Cy200/ATG conditioning, the patient received an HLA 2-locus-mismatched cord blood unit, and the total number of infused nucleated cells was 11.52 × 107/kg. Neutrophil engraftment was achieved on day +13, and a platelet count greater than 20 × 109/L was achieved on day ?50. The neutrophil oxidative burst was 100% normal with full donor lymphocyte reconstitution at 8 months post-transplant. This case highlights that unrelated donor CBT for CGD is potentially safe and feasible, even in early infancy, when an appropriately matched related or unrelated donor is unavailable.

KW - Chronic granulomatous disease

KW - Unrelated cord blood transplantation

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DO - 10.1007/s12185-010-0537-5

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JO - International Journal of Hematology

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Successful unrelated donor cord blood transplantation for chronic granulomatous disease

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Keywords

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