Abstract
In pentobarbital anesthetized rats, unilateral microinjection (500 ng) of the selective perikaryal excitotoxin, kainic acid, into the nucleus ambiguus promoted a significant suppression of arterial pressure, heart rate and cardiac contractility. The degree of such cardiovascular depression followed the order of heart contractility reduction (50.7%) > hypotension (28.9%) > bradycardia (20.8%) at the end of a 60-min postinjection period. We concluded that the nucleus ambiguus may exert its control on cardiac activities by both negative chronotropic and inotropic effects on the heart.
| Original language | English |
|---|---|
| Pages (from-to) | 57-62 |
| Number of pages | 6 |
| Journal | Neuroscience Letters |
| Volume | 47 |
| Issue number | 1 |
| DOIs | |
| State | Published - 01 06 1984 |
| Externally published | Yes |
Keywords
- bradycardia
- heart contractility reduction
- hypotension
- kainic acid
- nucleus ambiguus
- rat