Supramolecular chemistry on multi-walled carbon nanotubes decorated with Fe3O4 nanoparticles for controlled targeted drug delivery.

Yu Jen Lu; Shin Ming Li; Kuo Chen Wei; Shih Yi Yang; Yuan Li Huang; Hong Chieh Tsai; Chiung Yin Huang; Pin Yuan Chen; Shu Mei Chen; Chen Chi Ma; Jyh Ping Chen

Supramolecular chemistry on multi-walled carbon nanotubes decorated with Fe₃O₄ nanoparticles for controlled targeted drug delivery.

Yu Jen Lu
, Shin Ming Li
, Kuo Chen Wei
, Shih Yi Yang
, Yuan Li Huang
, Hong Chieh Tsai
, Chiung Yin Huang
, Pin Yuan Chen
, Shu Mei Chen
, Chen Chi Ma
, Jyh Ping Chen^*

^*Corresponding author for this work

Chang Gung Memorial Hospital
National Tsing Hua University

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

In this work, we combine the advantages of Multi-walled carbon nanotubes (MWCNTs) and iron oxide magnetic nanoparticles (MN) and develop a novel multifunctional magnetic MWCNTs. Poly(acrylic acid) was first functionalized MWCNT(PAA-MWCNTs) through free radical polymerization and decorated with MN(MN-PAA-MWCNTs) containing anti-cancer drug doxorubicin (DOX), folic acid (FA) (DOX-FA-MN-PAA-MWCNTs), and fluorescent dye (FITC). The proposed methodology provides dual targeted delivery of the anti-cancer drug to cancer cells under the guidance of a magnetic field and through ligand-receptor interactions while allowing real-time monitoring of drug treatment through dual-modal fluorescence and magnetic resonance imaging. The chemico-physical properties of MWCNTs were fully characterized by XPS, TEM and SQUID, in addition to its drug loading efficiency and drug releasing characteristics. Doxorubicin could be loaded to MWCNTs with high efficiency via stacking and enhance its cytotoxic activity toward human U87 glioma cells compared to free DOX. We confirmed that DOX-FA-MN-PAA-MWCNTs is efficiently taken up by cancer cells with subsequent intracellular release of DOX, which then translocates to the nucleus while the nanocarriers remain in the cytoplasm. These properties make DOX-FA-MN- PAA-MWCNTs a potential candidate for controlled targeted delivery of DOX for cancer treatment.

Original language	English
Title of host publication	7th Asian-Australasian Conference on Composite Materials 2010, ACCM 2010
Publisher	ACCM-7 Organizing Committee
Pages	804-807
Number of pages	4
ISBN (Print)	9781632660756
State	Published - 2010
Event	7th Asian-Australasian Conference on Composite Materials 2010, ACCM 2010 - Taipei, Taiwan Duration: 15 11 2010 → 18 11 2010

Publication series

Name	7th Asian-Australasian Conference on Composite Materials 2010, ACCM 2010
Volume	2

Conference

Conference	7th Asian-Australasian Conference on Composite Materials 2010, ACCM 2010
Country/Territory	Taiwan
City	Taipei
Period	15/11/10 → 18/11/10

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Doxorubicin
Drug delivery
Iron oxide magnetic nanoparticles
Multi-walled carbon nanotubes

Cite this

Lu, Y. J., Li, S. M., Wei, K. C., Yang, S. Y., Huang, Y. L., Tsai, H. C., Huang, C. Y., Chen, P. Y., Chen, S. M., Ma, C. C., & Chen, J. P. (2010). Supramolecular chemistry on multi-walled carbon nanotubes decorated with Fe₃O₄ nanoparticles for controlled targeted drug delivery. In 7th Asian-Australasian Conference on Composite Materials 2010, ACCM 2010 (pp. 804-807). (7th Asian-Australasian Conference on Composite Materials 2010, ACCM 2010; Vol. 2). ACCM-7 Organizing Committee.

Lu, Yu Jen ; Li, Shin Ming ; Wei, Kuo Chen et al. / Supramolecular chemistry on multi-walled carbon nanotubes decorated with Fe₃O₄ nanoparticles for controlled targeted drug delivery. 7th Asian-Australasian Conference on Composite Materials 2010, ACCM 2010. ACCM-7 Organizing Committee, 2010. pp. 804-807 (7th Asian-Australasian Conference on Composite Materials 2010, ACCM 2010).

@inproceedings{0f15f8a7594b42f5b3fcea229b13d3e8,

title = "Supramolecular chemistry on multi-walled carbon nanotubes decorated with Fe3O4 nanoparticles for controlled targeted drug delivery.",

abstract = "In this work, we combine the advantages of Multi-walled carbon nanotubes (MWCNTs) and iron oxide magnetic nanoparticles (MN) and develop a novel multifunctional magnetic MWCNTs. Poly(acrylic acid) was first functionalized MWCNT(PAA-MWCNTs) through free radical polymerization and decorated with MN(MN-PAA-MWCNTs) containing anti-cancer drug doxorubicin (DOX), folic acid (FA) (DOX-FA-MN-PAA-MWCNTs), and fluorescent dye (FITC). The proposed methodology provides dual targeted delivery of the anti-cancer drug to cancer cells under the guidance of a magnetic field and through ligand-receptor interactions while allowing real-time monitoring of drug treatment through dual-modal fluorescence and magnetic resonance imaging. The chemico-physical properties of MWCNTs were fully characterized by XPS, TEM and SQUID, in addition to its drug loading efficiency and drug releasing characteristics. Doxorubicin could be loaded to MWCNTs with high efficiency via stacking and enhance its cytotoxic activity toward human U87 glioma cells compared to free DOX. We confirmed that DOX-FA-MN-PAA-MWCNTs is efficiently taken up by cancer cells with subsequent intracellular release of DOX, which then translocates to the nucleus while the nanocarriers remain in the cytoplasm. These properties make DOX-FA-MN- PAA-MWCNTs a potential candidate for controlled targeted delivery of DOX for cancer treatment.",

keywords = "Doxorubicin, Drug delivery, Iron oxide magnetic nanoparticles, Multi-walled carbon nanotubes",

author = "Lu, \{Yu Jen\} and Li, \{Shin Ming\} and Wei, \{Kuo Chen\} and Yang, \{Shih Yi\} and Huang, \{Yuan Li\} and Tsai, \{Hong Chieh\} and Huang, \{Chiung Yin\} and Chen, \{Pin Yuan\} and Chen, \{Shu Mei\} and Ma, \{Chen Chi\} and Chen, \{Jyh Ping\}",

year = "2010",

language = "英语",

isbn = "9781632660756",

series = "7th Asian-Australasian Conference on Composite Materials 2010, ACCM 2010",

publisher = "ACCM-7 Organizing Committee",

pages = "804--807",

booktitle = "7th Asian-Australasian Conference on Composite Materials 2010, ACCM 2010",

note = "7th Asian-Australasian Conference on Composite Materials 2010, ACCM 2010 ; Conference date: 15-11-2010 Through 18-11-2010",

}

Lu, YJ, Li, SM, Wei, KC, Yang, SY, Huang, YL, Tsai, HC, Huang, CY, Chen, PY, Chen, SM, Ma, CC & Chen, JP 2010, Supramolecular chemistry on multi-walled carbon nanotubes decorated with Fe₃O₄ nanoparticles for controlled targeted drug delivery. in 7th Asian-Australasian Conference on Composite Materials 2010, ACCM 2010. 7th Asian-Australasian Conference on Composite Materials 2010, ACCM 2010, vol. 2, ACCM-7 Organizing Committee, pp. 804-807, 7th Asian-Australasian Conference on Composite Materials 2010, ACCM 2010, Taipei, Taiwan, 15/11/10.

Supramolecular chemistry on multi-walled carbon nanotubes decorated with Fe₃O₄ nanoparticles for controlled targeted drug delivery. / Lu, Yu Jen; Li, Shin Ming; Wei, Kuo Chen et al.
7th Asian-Australasian Conference on Composite Materials 2010, ACCM 2010. ACCM-7 Organizing Committee, 2010. p. 804-807 (7th Asian-Australasian Conference on Composite Materials 2010, ACCM 2010; Vol. 2).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Supramolecular chemistry on multi-walled carbon nanotubes decorated with Fe3O4 nanoparticles for controlled targeted drug delivery.

AU - Lu, Yu Jen

AU - Li, Shin Ming

AU - Wei, Kuo Chen

AU - Yang, Shih Yi

AU - Huang, Yuan Li

AU - Tsai, Hong Chieh

AU - Huang, Chiung Yin

AU - Chen, Pin Yuan

AU - Chen, Shu Mei

AU - Ma, Chen Chi

AU - Chen, Jyh Ping

PY - 2010

Y1 - 2010

N2 - In this work, we combine the advantages of Multi-walled carbon nanotubes (MWCNTs) and iron oxide magnetic nanoparticles (MN) and develop a novel multifunctional magnetic MWCNTs. Poly(acrylic acid) was first functionalized MWCNT(PAA-MWCNTs) through free radical polymerization and decorated with MN(MN-PAA-MWCNTs) containing anti-cancer drug doxorubicin (DOX), folic acid (FA) (DOX-FA-MN-PAA-MWCNTs), and fluorescent dye (FITC). The proposed methodology provides dual targeted delivery of the anti-cancer drug to cancer cells under the guidance of a magnetic field and through ligand-receptor interactions while allowing real-time monitoring of drug treatment through dual-modal fluorescence and magnetic resonance imaging. The chemico-physical properties of MWCNTs were fully characterized by XPS, TEM and SQUID, in addition to its drug loading efficiency and drug releasing characteristics. Doxorubicin could be loaded to MWCNTs with high efficiency via stacking and enhance its cytotoxic activity toward human U87 glioma cells compared to free DOX. We confirmed that DOX-FA-MN-PAA-MWCNTs is efficiently taken up by cancer cells with subsequent intracellular release of DOX, which then translocates to the nucleus while the nanocarriers remain in the cytoplasm. These properties make DOX-FA-MN- PAA-MWCNTs a potential candidate for controlled targeted delivery of DOX for cancer treatment.

AB - In this work, we combine the advantages of Multi-walled carbon nanotubes (MWCNTs) and iron oxide magnetic nanoparticles (MN) and develop a novel multifunctional magnetic MWCNTs. Poly(acrylic acid) was first functionalized MWCNT(PAA-MWCNTs) through free radical polymerization and decorated with MN(MN-PAA-MWCNTs) containing anti-cancer drug doxorubicin (DOX), folic acid (FA) (DOX-FA-MN-PAA-MWCNTs), and fluorescent dye (FITC). The proposed methodology provides dual targeted delivery of the anti-cancer drug to cancer cells under the guidance of a magnetic field and through ligand-receptor interactions while allowing real-time monitoring of drug treatment through dual-modal fluorescence and magnetic resonance imaging. The chemico-physical properties of MWCNTs were fully characterized by XPS, TEM and SQUID, in addition to its drug loading efficiency and drug releasing characteristics. Doxorubicin could be loaded to MWCNTs with high efficiency via stacking and enhance its cytotoxic activity toward human U87 glioma cells compared to free DOX. We confirmed that DOX-FA-MN-PAA-MWCNTs is efficiently taken up by cancer cells with subsequent intracellular release of DOX, which then translocates to the nucleus while the nanocarriers remain in the cytoplasm. These properties make DOX-FA-MN- PAA-MWCNTs a potential candidate for controlled targeted delivery of DOX for cancer treatment.

KW - Doxorubicin

KW - Drug delivery

KW - Iron oxide magnetic nanoparticles

KW - Multi-walled carbon nanotubes

UR - https://www.scopus.com/pages/publications/84905500209

M3 - 会议稿件

AN - SCOPUS:84905500209

SN - 9781632660756

T3 - 7th Asian-Australasian Conference on Composite Materials 2010, ACCM 2010

SP - 804

EP - 807

BT - 7th Asian-Australasian Conference on Composite Materials 2010, ACCM 2010

PB - ACCM-7 Organizing Committee

T2 - 7th Asian-Australasian Conference on Composite Materials 2010, ACCM 2010

Y2 - 15 November 2010 through 18 November 2010

ER -

Lu YJ, Li SM, Wei KC, Yang SY, Huang YL, Tsai HC et al. Supramolecular chemistry on multi-walled carbon nanotubes decorated with Fe₃O₄ nanoparticles for controlled targeted drug delivery. In 7th Asian-Australasian Conference on Composite Materials 2010, ACCM 2010. ACCM-7 Organizing Committee. 2010. p. 804-807. (7th Asian-Australasian Conference on Composite Materials 2010, ACCM 2010).