Surface acoustic wave sensor for c-reactive protein detection

Ming Jer Jeng; Mukta Sharma; Ying Chang Li; Yi Chen Lu; Chia Yu Yu; Chia Lung Tsai; Shiang Fu Huang; Liann Be Chang; Chao Sung Lai

doi:10.3390/s20226640

Surface acoustic wave sensor for c-reactive protein detection

Ming Jer Jeng, Mukta Sharma, Ying Chang Li, Yi Chen Lu, Chia Yu Yu, Chia Lung Tsai^*, Shiang Fu Huang, Liann Be Chang, Chao Sung Lai

^*Corresponding author for this work

Chang Gung University

Research output: Contribution to journal › Journal Letter › peer-review

23 Scopus citations

Abstract

A surface acoustic wave (SAW) sensor was investigated for its application in C-reactive protein (CRP) detection. Piezoelectric lithium niobate (LiNbO₃) substrates were used to study their frequency response characteristics in a SAW sensor with a CRP sensing area. After the fabrication of the SAW sensor, the immobilization process was performed for CRP/anti-CRP interaction. The CRP/anti-CRP interaction can be detected as mass variations in the sensing area. These mass variations may produce changes in the amplitude of sensor response. It was clearly observed that a CRP concentration of 0.1 µg/mL can be detected in the proposed SAW sensor. A good fitting linear relationship between the detected insertion loss (amplitude) and the concentrations of CRP from 0.1 µg/mL to 1 mg/mL was obtained. The detected shifts in the amplitude of insertion loss in SAW sensors for different CRP concentrations may be useful in the diagnosis of risk of cardiovascular diseases.

Original language	English
Article number	6640
Pages (from-to)	1-11
Number of pages	11
Journal	Sensors
Volume	20
Issue number	22
DOIs	https://doi.org/10.3390/s20226640
State	Published - 02 11 2020

Bibliographical note

Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

C-reactive protein
Piezoelectric lithium niobate
Surface acoustic wave

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/s20226640

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title = "Surface acoustic wave sensor for c-reactive protein detection",

abstract = "A surface acoustic wave (SAW) sensor was investigated for its application in C-reactive protein (CRP) detection. Piezoelectric lithium niobate (LiNbO3) substrates were used to study their frequency response characteristics in a SAW sensor with a CRP sensing area. After the fabrication of the SAW sensor, the immobilization process was performed for CRP/anti-CRP interaction. The CRP/anti-CRP interaction can be detected as mass variations in the sensing area. These mass variations may produce changes in the amplitude of sensor response. It was clearly observed that a CRP concentration of 0.1 µg/mL can be detected in the proposed SAW sensor. A good fitting linear relationship between the detected insertion loss (amplitude) and the concentrations of CRP from 0.1 µg/mL to 1 mg/mL was obtained. The detected shifts in the amplitude of insertion loss in SAW sensors for different CRP concentrations may be useful in the diagnosis of risk of cardiovascular diseases.",

keywords = "C-reactive protein, Piezoelectric lithium niobate, Surface acoustic wave",

author = "Jeng, \{Ming Jer\} and Mukta Sharma and Li, \{Ying Chang\} and Lu, \{Yi Chen\} and Yu, \{Chia Yu\} and Tsai, \{Chia Lung\} and Huang, \{Shiang Fu\} and Chang, \{Liann Be\} and Lai, \{Chao Sung\}",

note = "Publisher Copyright: {\textcopyright} 2020 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2020",

month = nov,

day = "2",

doi = "10.3390/s20226640",

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AU - Jeng, Ming Jer

AU - Sharma, Mukta

AU - Li, Ying Chang

AU - Lu, Yi Chen

AU - Yu, Chia Yu

AU - Tsai, Chia Lung

AU - Huang, Shiang Fu

AU - Chang, Liann Be

AU - Lai, Chao Sung

PY - 2020/11/2

Y1 - 2020/11/2

N2 - A surface acoustic wave (SAW) sensor was investigated for its application in C-reactive protein (CRP) detection. Piezoelectric lithium niobate (LiNbO3) substrates were used to study their frequency response characteristics in a SAW sensor with a CRP sensing area. After the fabrication of the SAW sensor, the immobilization process was performed for CRP/anti-CRP interaction. The CRP/anti-CRP interaction can be detected as mass variations in the sensing area. These mass variations may produce changes in the amplitude of sensor response. It was clearly observed that a CRP concentration of 0.1 µg/mL can be detected in the proposed SAW sensor. A good fitting linear relationship between the detected insertion loss (amplitude) and the concentrations of CRP from 0.1 µg/mL to 1 mg/mL was obtained. The detected shifts in the amplitude of insertion loss in SAW sensors for different CRP concentrations may be useful in the diagnosis of risk of cardiovascular diseases.

AB - A surface acoustic wave (SAW) sensor was investigated for its application in C-reactive protein (CRP) detection. Piezoelectric lithium niobate (LiNbO3) substrates were used to study their frequency response characteristics in a SAW sensor with a CRP sensing area. After the fabrication of the SAW sensor, the immobilization process was performed for CRP/anti-CRP interaction. The CRP/anti-CRP interaction can be detected as mass variations in the sensing area. These mass variations may produce changes in the amplitude of sensor response. It was clearly observed that a CRP concentration of 0.1 µg/mL can be detected in the proposed SAW sensor. A good fitting linear relationship between the detected insertion loss (amplitude) and the concentrations of CRP from 0.1 µg/mL to 1 mg/mL was obtained. The detected shifts in the amplitude of insertion loss in SAW sensors for different CRP concentrations may be useful in the diagnosis of risk of cardiovascular diseases.

KW - C-reactive protein

KW - Piezoelectric lithium niobate

KW - Surface acoustic wave

UR - https://www.scopus.com/pages/publications/85096355394

U2 - 10.3390/s20226640

DO - 10.3390/s20226640

M3 - 快报

C2 - 33228249

AN - SCOPUS:85096355394

SN - 1424-8220

VL - 20

SP - 1

EP - 11

JO - Sensors

JF - Sensors

IS - 22

M1 - 6640

ER -

Surface acoustic wave sensor for c-reactive protein detection

Abstract

Bibliographical note

Keywords

UN SDGs

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