Surface plasmon resonance biosensor incorporated in a michelson interferometer with enhanced sensitivity

Wu Yuan; H. P. Ho; C. L. Wong; S. K. Kong; Chinlon Lin

doi:10.1109/JSEN.2006.884982

Surface plasmon resonance biosensor incorporated in a michelson interferometer with enhanced sensitivity

Wu Yuan^*
, H. P. Ho
, C. L. Wong
, S. K. Kong
, Chinlon Lin

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

59 Scopus citations

Abstract

A novel double-pass phase-sensitive surface plasmon resonance (SPR) biosensor based on a Michelson interferometer with differential phase interrogation is presented. The new setup provides an intrinsic resolution enhancement of up to two times in terms of achievable detection sensitivity due to an amplification effect in the SPR phase change when we place the SPR sensor head in the signal arm of the interferometer so that the interrogating optical beam traverses the sensor surface twice. Experimental results obtained from saltwater mixtures and antibody-antigen binding reactions confirmed the expected sensitivity enhancement as compared to the conventional SPR biosensor based on a Mach-Zehnder interferometer.

Original language	English
Pages (from-to)	70-73
Number of pages	4
Journal	IEEE Sensors Journal
Volume	7
Issue number	1
DOIs	https://doi.org/10.1109/JSEN.2006.884982
State	Published - 01 2007
Externally published	Yes

Keywords

Biosensor
Interferometry
Phase interrogation
Surface plasmon resonance

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10.1109/JSEN.2006.884982

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title = "Surface plasmon resonance biosensor incorporated in a michelson interferometer with enhanced sensitivity",

abstract = "A novel double-pass phase-sensitive surface plasmon resonance (SPR) biosensor based on a Michelson interferometer with differential phase interrogation is presented. The new setup provides an intrinsic resolution enhancement of up to two times in terms of achievable detection sensitivity due to an amplification effect in the SPR phase change when we place the SPR sensor head in the signal arm of the interferometer so that the interrogating optical beam traverses the sensor surface twice. Experimental results obtained from saltwater mixtures and antibody-antigen binding reactions confirmed the expected sensitivity enhancement as compared to the conventional SPR biosensor based on a Mach-Zehnder interferometer.",

keywords = "Biosensor, Interferometry, Phase interrogation, Surface plasmon resonance",

author = "Wu Yuan and Ho, \{H. P.\} and Wong, \{C. L.\} and Kong, \{S. K.\} and Chinlon Lin",

year = "2007",

month = jan,

doi = "10.1109/JSEN.2006.884982",

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AU - Yuan, Wu

AU - Ho, H. P.

AU - Wong, C. L.

AU - Kong, S. K.

AU - Lin, Chinlon

PY - 2007/1

Y1 - 2007/1

N2 - A novel double-pass phase-sensitive surface plasmon resonance (SPR) biosensor based on a Michelson interferometer with differential phase interrogation is presented. The new setup provides an intrinsic resolution enhancement of up to two times in terms of achievable detection sensitivity due to an amplification effect in the SPR phase change when we place the SPR sensor head in the signal arm of the interferometer so that the interrogating optical beam traverses the sensor surface twice. Experimental results obtained from saltwater mixtures and antibody-antigen binding reactions confirmed the expected sensitivity enhancement as compared to the conventional SPR biosensor based on a Mach-Zehnder interferometer.

AB - A novel double-pass phase-sensitive surface plasmon resonance (SPR) biosensor based on a Michelson interferometer with differential phase interrogation is presented. The new setup provides an intrinsic resolution enhancement of up to two times in terms of achievable detection sensitivity due to an amplification effect in the SPR phase change when we place the SPR sensor head in the signal arm of the interferometer so that the interrogating optical beam traverses the sensor surface twice. Experimental results obtained from saltwater mixtures and antibody-antigen binding reactions confirmed the expected sensitivity enhancement as compared to the conventional SPR biosensor based on a Mach-Zehnder interferometer.

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KW - Interferometry

KW - Phase interrogation

KW - Surface plasmon resonance

UR - https://www.scopus.com/pages/publications/33846267981

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DO - 10.1109/JSEN.2006.884982

M3 - 文章

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SP - 70

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JO - IEEE Sensors Journal

JF - IEEE Sensors Journal

IS - 1

ER -

Surface plasmon resonance biosensor incorporated in a michelson interferometer with enhanced sensitivity

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Keywords

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