Survival of second and multiple primary tumors in patients with oral cavity squamous cell carcinoma in the betel quid chewing area

Chun Ta Liao; Chung Jan Kang; Joseph Tung Chieh Chang; Hung Ming Wang; Shu Hang Ng; Chuen Hsueh; Li Yu Lee; Chih Hung Lin; Ann Joy Cheng; I. How Chen; Shiang Fu Huang; Tzu Chen Yen

doi:10.1016/j.oraloncology.2006.10.003

Survival of second and multiple primary tumors in patients with oral cavity squamous cell carcinoma in the betel quid chewing area

Chun Ta Liao
, Chung Jan Kang
, Joseph Tung Chieh Chang
, Hung Ming Wang
, Shu Hang Ng
, Chuen Hsueh
, Li Yu Lee
, Chih Hung Lin
, Ann Joy Cheng
, I. How Chen
, Shiang Fu Huang
, Tzu Chen Yen^*

^*Corresponding author for this work

Chang Gung University
Chang Gung Memorial Hospital

Research output: Contribution to journal › Journal Article › peer-review

86 Scopus citations

Abstract

We report the incidence, risk factor(s), and overall survival (OS) of second/multiple primary tumors (SPTs/MPTs) in oral cavity squamous cell carcinoma (OSCC) patients in betel quid chewing areas. Of 816 untreated OSCC patients who had radical surgery, 15.7% had either synchronous or metachronous SPTs. The SPTs (70.3%) were at the oral cavity. SPTs (18.8%) developed third primary tumors, with a significantly higher incidence in synchromous than metachronous SPTs (p = 0.001). An optimal, but significantly lower, 5-year OS was observed in patients with SPTs/MPTs than without (54.0% vs. 67.2%, p = 0.0195). By multivariate analyses, OSCC sub-sites (p = 0.006) and lymphatic permeation (p = 0.040) were independent risk factors for SPT rate. A significantly higher 5-year OS was observed in SPT patients receiving a second radical surgery at the oral cavity/soft palate than patients that did not (p = 0.0001). A good survival rate can be obtained for OSCC patients with resectable SPTs/MPTs.

Original language	English
Pages (from-to)	811-819
Number of pages	9
Journal	Oral Oncology
Volume	43
Issue number	8
DOIs	https://doi.org/10.1016/j.oraloncology.2006.10.003
State	Published - 09 2007

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Betel quid chewing
Multiple primary tumors
Oral cavity cancer
Second primary tumors
Survival

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10.1016/j.oraloncology.2006.10.003

Cite this

Liao, C. T., Kang, C. J., Chang, J. T. C., Wang, H. M., Ng, S. H., Hsueh, C., Lee, L. Y., Lin, C. H., Cheng, A. J., Chen, I. H., Huang, S. F., & Yen, T. C. (2007). Survival of second and multiple primary tumors in patients with oral cavity squamous cell carcinoma in the betel quid chewing area. Oral Oncology, 43(8), 811-819. https://doi.org/10.1016/j.oraloncology.2006.10.003

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title = "Survival of second and multiple primary tumors in patients with oral cavity squamous cell carcinoma in the betel quid chewing area",

abstract = "We report the incidence, risk factor(s), and overall survival (OS) of second/multiple primary tumors (SPTs/MPTs) in oral cavity squamous cell carcinoma (OSCC) patients in betel quid chewing areas. Of 816 untreated OSCC patients who had radical surgery, 15.7\% had either synchronous or metachronous SPTs. The SPTs (70.3\%) were at the oral cavity. SPTs (18.8\%) developed third primary tumors, with a significantly higher incidence in synchromous than metachronous SPTs (p = 0.001). An optimal, but significantly lower, 5-year OS was observed in patients with SPTs/MPTs than without (54.0\% vs. 67.2\%, p = 0.0195). By multivariate analyses, OSCC sub-sites (p = 0.006) and lymphatic permeation (p = 0.040) were independent risk factors for SPT rate. A significantly higher 5-year OS was observed in SPT patients receiving a second radical surgery at the oral cavity/soft palate than patients that did not (p = 0.0001). A good survival rate can be obtained for OSCC patients with resectable SPTs/MPTs.",

keywords = "Betel quid chewing, Multiple primary tumors, Oral cavity cancer, Second primary tumors, Survival",

author = "Liao, \{Chun Ta\} and Kang, \{Chung Jan\} and Chang, \{Joseph Tung Chieh\} and Wang, \{Hung Ming\} and Ng, \{Shu Hang\} and Chuen Hsueh and Lee, \{Li Yu\} and Lin, \{Chih Hung\} and Cheng, \{Ann Joy\} and Chen, \{I. How\} and Huang, \{Shiang Fu\} and Yen, \{Tzu Chen\}",

year = "2007",

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doi = "10.1016/j.oraloncology.2006.10.003",

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volume = "43",

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T1 - Survival of second and multiple primary tumors in patients with oral cavity squamous cell carcinoma in the betel quid chewing area

AU - Liao, Chun Ta

AU - Kang, Chung Jan

AU - Chang, Joseph Tung Chieh

AU - Wang, Hung Ming

AU - Ng, Shu Hang

AU - Hsueh, Chuen

AU - Lee, Li Yu

AU - Lin, Chih Hung

AU - Cheng, Ann Joy

AU - Chen, I. How

AU - Huang, Shiang Fu

AU - Yen, Tzu Chen

PY - 2007/9

Y1 - 2007/9

N2 - We report the incidence, risk factor(s), and overall survival (OS) of second/multiple primary tumors (SPTs/MPTs) in oral cavity squamous cell carcinoma (OSCC) patients in betel quid chewing areas. Of 816 untreated OSCC patients who had radical surgery, 15.7% had either synchronous or metachronous SPTs. The SPTs (70.3%) were at the oral cavity. SPTs (18.8%) developed third primary tumors, with a significantly higher incidence in synchromous than metachronous SPTs (p = 0.001). An optimal, but significantly lower, 5-year OS was observed in patients with SPTs/MPTs than without (54.0% vs. 67.2%, p = 0.0195). By multivariate analyses, OSCC sub-sites (p = 0.006) and lymphatic permeation (p = 0.040) were independent risk factors for SPT rate. A significantly higher 5-year OS was observed in SPT patients receiving a second radical surgery at the oral cavity/soft palate than patients that did not (p = 0.0001). A good survival rate can be obtained for OSCC patients with resectable SPTs/MPTs.

AB - We report the incidence, risk factor(s), and overall survival (OS) of second/multiple primary tumors (SPTs/MPTs) in oral cavity squamous cell carcinoma (OSCC) patients in betel quid chewing areas. Of 816 untreated OSCC patients who had radical surgery, 15.7% had either synchronous or metachronous SPTs. The SPTs (70.3%) were at the oral cavity. SPTs (18.8%) developed third primary tumors, with a significantly higher incidence in synchromous than metachronous SPTs (p = 0.001). An optimal, but significantly lower, 5-year OS was observed in patients with SPTs/MPTs than without (54.0% vs. 67.2%, p = 0.0195). By multivariate analyses, OSCC sub-sites (p = 0.006) and lymphatic permeation (p = 0.040) were independent risk factors for SPT rate. A significantly higher 5-year OS was observed in SPT patients receiving a second radical surgery at the oral cavity/soft palate than patients that did not (p = 0.0001). A good survival rate can be obtained for OSCC patients with resectable SPTs/MPTs.

KW - Betel quid chewing

KW - Multiple primary tumors

KW - Oral cavity cancer

KW - Second primary tumors

KW - Survival

UR - https://www.scopus.com/pages/publications/34547913794

U2 - 10.1016/j.oraloncology.2006.10.003

DO - 10.1016/j.oraloncology.2006.10.003

M3 - 文章

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AN - SCOPUS:34547913794

SN - 1368-8375

VL - 43

SP - 811

EP - 819

JO - Oral Oncology

JF - Oral Oncology

IS - 8

ER -

Survival of second and multiple primary tumors in patients with oral cavity squamous cell carcinoma in the betel quid chewing area

Abstract

UN SDGs

Keywords

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