Survival Outcomes of Patients with Esophageal Cancer Who Did Not Proceed to Surgery after Neoadjuvant Treatment

Chun Ling Chi; Xing Gao; Hsiang Yu Hsieh; Yi Hsuan Cheng; Zhi Hao Yang; Yin Kai Chao

doi:10.3390/cancers15164049

Survival Outcomes of Patients with Esophageal Cancer Who Did Not Proceed to Surgery after Neoadjuvant Treatment

Chun Ling Chi
, Xing Gao
, Hsiang Yu Hsieh
, Yi Hsuan Cheng
, Zhi Hao Yang
, Yin Kai Chao^*

^*Corresponding author for this work

Chang Gung University
Erasmus University Rotterdam

Research output: Contribution to journal › Journal Article › peer-review

5 Scopus citations

Abstract

BACKGROUND: This retrospective study examined outcomes in esophageal squamous cell carcinoma (ESCC) patients who did not undergo surgical resection after neoadjuvant chemoradiotherapy (nCRT).

METHODS: Patients receiving nCRT between 2012 and 2020 were divided into two groups: group 1 (scheduled surgery) and group 2 (no surgery). Group 2 was further categorized into subgroups based on reasons for not proceeding to surgery: group 2a (disease progression), group 2b (poor general conditions), and group 2c (patient refusal). Overall survival (OS) was the primary outcome.

RESULTS: Group 1 comprised 145 patients, while subgroups 2a, 2b, and 2c comprised 24, 16, and 31 patients, respectively. The 3-year OS rate was significantly lower in group 2 compared with group 1 (34% versus 56%, p < 0.001). A subgroup analysis showed varying 3-year OS rates: 13% for group 2a, 25% for group 2b, and 58% for group 2c ( p < 0.001). Propensity score matching for group 2c and group 1 revealed no significant difference in 3-year OS rates ( p = 0.91).

CONCLUSION: One-third of ESCC patients receiving nCRT did not undergo surgical resection. Overall survival in this group was generally poorer, except for those who refused surgery (group 2c).

Original language	English
Article number	4049
Journal	Cancers
Volume	15
Issue number	16
DOIs	https://doi.org/10.3390/cancers15164049
State	Published - 10 08 2023
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2023 by the authors.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

esophageal cancer
esophagectomy
neoadjuvant treatment
non-surgical treatment
patient refusal

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10.3390/cancers15164049

Cite this

@article{377ac2cdba924f6bab946edf42e43999,

title = "Survival Outcomes of Patients with Esophageal Cancer Who Did Not Proceed to Surgery after Neoadjuvant Treatment",

abstract = "BACKGROUND: This retrospective study examined outcomes in esophageal squamous cell carcinoma (ESCC) patients who did not undergo surgical resection after neoadjuvant chemoradiotherapy (nCRT).METHODS: Patients receiving nCRT between 2012 and 2020 were divided into two groups: group 1 (scheduled surgery) and group 2 (no surgery). Group 2 was further categorized into subgroups based on reasons for not proceeding to surgery: group 2a (disease progression), group 2b (poor general conditions), and group 2c (patient refusal). Overall survival (OS) was the primary outcome.RESULTS: Group 1 comprised 145 patients, while subgroups 2a, 2b, and 2c comprised 24, 16, and 31 patients, respectively. The 3-year OS rate was significantly lower in group 2 compared with group 1 (34\% versus 56\%, p < 0.001). A subgroup analysis showed varying 3-year OS rates: 13\% for group 2a, 25\% for group 2b, and 58\% for group 2c ( p < 0.001). Propensity score matching for group 2c and group 1 revealed no significant difference in 3-year OS rates ( p = 0.91). CONCLUSION: One-third of ESCC patients receiving nCRT did not undergo surgical resection. Overall survival in this group was generally poorer, except for those who refused surgery (group 2c).",

keywords = "esophageal cancer, esophagectomy, neoadjuvant treatment, non-surgical treatment, patient refusal",

author = "Chi, \{Chun Ling\} and Xing Gao and Hsieh, \{Hsiang Yu\} and Cheng, \{Yi Hsuan\} and Yang, \{Zhi Hao\} and Chao, \{Yin Kai\}",

note = "Publisher Copyright: {\textcopyright} 2023 by the authors.",

year = "2023",

month = aug,

day = "10",

doi = "10.3390/cancers15164049",

language = "英语",

volume = "15",

journal = "Cancers",

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}

TY - JOUR

T1 - Survival Outcomes of Patients with Esophageal Cancer Who Did Not Proceed to Surgery after Neoadjuvant Treatment

AU - Chi, Chun Ling

AU - Gao, Xing

AU - Hsieh, Hsiang Yu

AU - Cheng, Yi Hsuan

AU - Yang, Zhi Hao

AU - Chao, Yin Kai

PY - 2023/8/10

Y1 - 2023/8/10

N2 - BACKGROUND: This retrospective study examined outcomes in esophageal squamous cell carcinoma (ESCC) patients who did not undergo surgical resection after neoadjuvant chemoradiotherapy (nCRT).METHODS: Patients receiving nCRT between 2012 and 2020 were divided into two groups: group 1 (scheduled surgery) and group 2 (no surgery). Group 2 was further categorized into subgroups based on reasons for not proceeding to surgery: group 2a (disease progression), group 2b (poor general conditions), and group 2c (patient refusal). Overall survival (OS) was the primary outcome.RESULTS: Group 1 comprised 145 patients, while subgroups 2a, 2b, and 2c comprised 24, 16, and 31 patients, respectively. The 3-year OS rate was significantly lower in group 2 compared with group 1 (34% versus 56%, p < 0.001). A subgroup analysis showed varying 3-year OS rates: 13% for group 2a, 25% for group 2b, and 58% for group 2c ( p < 0.001). Propensity score matching for group 2c and group 1 revealed no significant difference in 3-year OS rates ( p = 0.91). CONCLUSION: One-third of ESCC patients receiving nCRT did not undergo surgical resection. Overall survival in this group was generally poorer, except for those who refused surgery (group 2c).

AB - BACKGROUND: This retrospective study examined outcomes in esophageal squamous cell carcinoma (ESCC) patients who did not undergo surgical resection after neoadjuvant chemoradiotherapy (nCRT).METHODS: Patients receiving nCRT between 2012 and 2020 were divided into two groups: group 1 (scheduled surgery) and group 2 (no surgery). Group 2 was further categorized into subgroups based on reasons for not proceeding to surgery: group 2a (disease progression), group 2b (poor general conditions), and group 2c (patient refusal). Overall survival (OS) was the primary outcome.RESULTS: Group 1 comprised 145 patients, while subgroups 2a, 2b, and 2c comprised 24, 16, and 31 patients, respectively. The 3-year OS rate was significantly lower in group 2 compared with group 1 (34% versus 56%, p < 0.001). A subgroup analysis showed varying 3-year OS rates: 13% for group 2a, 25% for group 2b, and 58% for group 2c ( p < 0.001). Propensity score matching for group 2c and group 1 revealed no significant difference in 3-year OS rates ( p = 0.91). CONCLUSION: One-third of ESCC patients receiving nCRT did not undergo surgical resection. Overall survival in this group was generally poorer, except for those who refused surgery (group 2c).

KW - esophageal cancer

KW - esophagectomy

KW - neoadjuvant treatment

KW - non-surgical treatment

KW - patient refusal

UR - https://www.scopus.com/pages/publications/85168801514

U2 - 10.3390/cancers15164049

DO - 10.3390/cancers15164049

M3 - 文章

C2 - 37627076

AN - SCOPUS:85168801514

SN - 2072-6694

VL - 15

JO - Cancers

JF - Cancers

IS - 16

M1 - 4049

ER -

Survival Outcomes of Patients with Esophageal Cancer Who Did Not Proceed to Surgery after Neoadjuvant Treatment

Abstract

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