Abstract
Hydroxyethyl cellulose (HEC) is used as a neutral excipient in microbicides used against sexually transmitted pathogens. However, HEC inhibits the infection of cervical epithelial cells by Chlamydia trachomatis at pH 5 in a concentration-dependent manner. At pH 7, infection is inversely dependent on the concentration of HEC, possibly due to pH-dependent calcium sequestration.
Original language | English |
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Pages (from-to) | 2660-2662 |
Number of pages | 3 |
Journal | Antimicrobial Agents and Chemotherapy |
Volume | 52 |
Issue number | 7 |
DOIs | |
State | Published - 07 2008 |
Externally published | Yes |