Susceptibility of Chlamydia trachomatis to the excipient hydroxyethyl cellulose: pH and concentration dependence of antimicrobial activity

Ali A. Abdul Sater, David M. Ojcius, Matthew P. Meyer

Research output: Contribution to journalJournal Article peer-review

3 Scopus citations

Abstract

Hydroxyethyl cellulose (HEC) is used as a neutral excipient in microbicides used against sexually transmitted pathogens. However, HEC inhibits the infection of cervical epithelial cells by Chlamydia trachomatis at pH 5 in a concentration-dependent manner. At pH 7, infection is inversely dependent on the concentration of HEC, possibly due to pH-dependent calcium sequestration.

Original languageEnglish
Pages (from-to)2660-2662
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume52
Issue number7
DOIs
StatePublished - 07 2008
Externally publishedYes

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