Susceptibility of Chlamydia trachomatis to the excipient hydroxyethyl cellulose: pH and concentration dependence of antimicrobial activity

Ali A. Abdul Sater; David M. Ojcius; Matthew P. Meyer

doi:10.1128/AAC.00785-07

Susceptibility of Chlamydia trachomatis to the excipient hydroxyethyl cellulose: pH and concentration dependence of antimicrobial activity

Ali A. Abdul Sater
, David M. Ojcius
, Matthew P. Meyer

University of California Merced

Research output: Contribution to journal › Journal Article › peer-review

3 Scopus citations

Abstract

Hydroxyethyl cellulose (HEC) is used as a neutral excipient in microbicides used against sexually transmitted pathogens. However, HEC inhibits the infection of cervical epithelial cells by Chlamydia trachomatis at pH 5 in a concentration-dependent manner. At pH 7, infection is inversely dependent on the concentration of HEC, possibly due to pH-dependent calcium sequestration.

Original language	English
Pages (from-to)	2660-2662
Number of pages	3
Journal	Antimicrobial Agents and Chemotherapy
Volume	52
Issue number	7
DOIs	https://doi.org/10.1128/AAC.00785-07
State	Published - 07 2008
Externally published	Yes

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10.1128/AAC.00785-07

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title = "Susceptibility of Chlamydia trachomatis to the excipient hydroxyethyl cellulose: pH and concentration dependence of antimicrobial activity",

abstract = "Hydroxyethyl cellulose (HEC) is used as a neutral excipient in microbicides used against sexually transmitted pathogens. However, HEC inhibits the infection of cervical epithelial cells by Chlamydia trachomatis at pH 5 in a concentration-dependent manner. At pH 7, infection is inversely dependent on the concentration of HEC, possibly due to pH-dependent calcium sequestration.",

author = "\{Abdul Sater\}, \{Ali A.\} and Ojcius, \{David M.\} and Meyer, \{Matthew P.\}",

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AU - Ojcius, David M.

AU - Meyer, Matthew P.

PY - 2008/7

Y1 - 2008/7

N2 - Hydroxyethyl cellulose (HEC) is used as a neutral excipient in microbicides used against sexually transmitted pathogens. However, HEC inhibits the infection of cervical epithelial cells by Chlamydia trachomatis at pH 5 in a concentration-dependent manner. At pH 7, infection is inversely dependent on the concentration of HEC, possibly due to pH-dependent calcium sequestration.

AB - Hydroxyethyl cellulose (HEC) is used as a neutral excipient in microbicides used against sexually transmitted pathogens. However, HEC inhibits the infection of cervical epithelial cells by Chlamydia trachomatis at pH 5 in a concentration-dependent manner. At pH 7, infection is inversely dependent on the concentration of HEC, possibly due to pH-dependent calcium sequestration.

UR - https://www.scopus.com/pages/publications/46249092186

U2 - 10.1128/AAC.00785-07

DO - 10.1128/AAC.00785-07

M3 - 文章

C2 - 18411317

AN - SCOPUS:46249092186

SN - 0066-4804

VL - 52

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EP - 2662

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 7

ER -

Susceptibility of Chlamydia trachomatis to the excipient hydroxyethyl cellulose: pH and concentration dependence of antimicrobial activity

Abstract

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